Results 181 to 190 of about 869,733 (343)
Pharmacotherapeutics of SARS-CoV-2
Journal of Family Medicine and Primary Care, 2022 Harish Gupta, Nitu Nigam, Satish Kumar
openaire +3 more sources
NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA
Advanced Science, EarlyView.MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen +13 more
wiley +1 more source
Designing a novel mRNA vaccine against SARS-CoV-2: An immunoinformatics approach
, 2020 Ishtiaque Ahammad, Samia Sultana Lira
openalex +1 more source
Advanced Science, EarlyView.Researchers developed SCORCH2, an advanced machine‐learning scoring function for virtual screening that combines two complementary XGBoost models to re‐evaluate protein‐ligand binding plausibility. The method demonstrates superior performance on standard benchmarks, shows excellent generalization to previously unseen protein targets, and provides ...
Lin Chen +3 more
wiley +1 more source
Advanced Science, EarlyView.Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil +12 more
wiley +1 more source
Advanced Science, EarlyView.The first low‐temperature interfacial evaporation air sterilization technology is presented. It is based on a superhydrophilic ferromagnetic micro/nano‐structured stainless‐steel filter, showing ultra‐efficient inductive heating. This technology has demonstrated over 99.6% of SARS‐CoV‐2 and RSV elimination at temperatures in the 60–80 °C range.
Arnau Fons +15 more
wiley +1 more source
Inhibition of N-linked Glycosylation by Tunicamycin May Contribute to The Treatment of SARS-CoV-2
, 2020 Ali Adel Dawood +1 more
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Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles
Advanced Science, EarlyView.A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu +13 more
wiley +1 more source