Results 201 to 210 of about 1,048,158 (273)

Multimorbidity and animal models

Animal Models and Experimental Medicine, EarlyView.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source

Transforming RNA Degradation into Accurate RNA Detection: RNase I–Assisted Rolling Circle Amplification for Clinical Samples

Angewandte Chemie, EarlyView.
Here, we transform this otherwise destructive enzymatic activity into a powerful diagnostic advantage through an RNase I–assisted rolling circle amplification (RI‐RCA) strategy. By integrating controlled RNase I–mediated RNA digestion with circular DNA templates, this approach enables direct and highly sensitive detection of target RNA sequences. Using
Amal Mathai, Cheng‐Yu Lee, Zijie Zhang, Jimmy Gu, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

High-Fidelity and Cost-Effective Engineering of SARS-CoV-2. [PDF]

Viruses
Olguin-Nava M, Hennig T, Börtlein C, Bohn P, Ambi UB, Gabel A, Günter LM, Gribling-Burrer AS, Schmidt N, Caliskan N, Dölken L, Munschauer M, Smyth RP.   +12 more
europepmc   +1 more source

Monitoring the infection of SARS-CoV-2 and the development of diagnostic tools

, 2020
Antonio Angeloni, Antonella Farina, Cristiano Ialongo, Patrizia Mancini, Emanuela Anastasi   +4 more
openalex   +2 more sources

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Genomic epidemiology of SARS-CoV-2 in Peru from 2020 to 2024. [PDF]

Commun Med (Lond)
Sobkowiak B, Langdon A, Romero PE, Carrasco-Escobar G, Villa D, Cava Miller R, Cornejo Villanueva V, Dávila-Barclay A, Cuicapuza D, Salvatierra G, González L, Ayzanoa B, Huancachoque J, Marcos-Carbajal P, Gómez de la Torre JC, Barletta C, Chenet SM, Tapia-Limonchi R, Ballón J, Fernández P, Valderrama R, Leguía M, Delgado-Ratto C, Gotuzzo E, Zamudio C, Lescano W, Cárcamo C, Hurtado V, Lope-Pari P, Padilla-Rojas C, Jiménez-Vásquez V, Escalante-Maldonado O, Araujo-Castillo RV, Cabezas C, Colijn C, Tsukayama P.   +35 more
europepmc   +1 more source

Confined B‐Cell Reconstruction and High T‐Cell Clonality Define Clinical Response to Cladribine Treatment

Annals of Neurology, EarlyView.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M. Schumann, Jan D. Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab   +8 more
wiley   +1 more source

The seven enigmas of SARS-CoV-2: from the past to the future. [PDF]

J Hum Immun
Andreakos E, Arkin L, Bastard P, Bolze A, Borghesi A, Brodin P, Casanova JL, Casari G, Cobat A, Drolet B, Fellay J, Hsieh E, Meyts I, Mogensen TH, Sancho-Shimizu V, Spaan AN, Su HC, Vinh DC, Yatim A, Zhang Q, Zhang SY, COVID Human Genetic Effort+.   +21 more
europepmc   +1 more source

Comprehending the Membrane Properties for Emulation in Organs‐on‐a‐Chip

Advanced NanoBiomed Research, EarlyView.
The advent of organ‐on‐chip models allows closer emulation of in vivo conditions, leading to effective, less costly, and specific drugs. Although a number of membrane‐based on‐chip models exist, better emulating functional models need to be devised for organ simulations.
Tanmayee Makarand Sathe, Dhananjay Shrikrishna Bodas   +1 more
wiley   +1 more source

Lung infection in orally inoculated SARS-CoV-2 hamsters. [PDF]

PLoS One
Picard-Meyer E, Wasniewski M, Boué F, Torres-Maravilla E, Saint-Criq V, Larcher T, Beissat K, Jacouton E, Holowacz S, Waligora-Dupriet AJ, Langella P, Servat A, Monchatre-Leroy E.   +12 more
europepmc   +1 more source