Results 281 to 290 of about 869,733 (343)

In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins

ChemBioChem, EarlyView.
This review evaluates engineered (semi)autonomous cell systems for the biosynthesis and incorporation of noncanonical amino acids (ncAAs) into proteins. While semi‐autonomous cells convert supplied precursors into ncAAs autonomous cells integrate biosynthetic pathways that produce these building blocks intracellularly.
Jan Hendrik Illies, Tim Moritz Weber, Ivana Drienovská   +2 more
wiley   +1 more source

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

, 2020
Kizzmekia S. Corbett, Darin K. Edwards, Sarah R. Leist, Olubukola M. Abiona, Seyhan Boyoglu-Barnum, Rebecca A. Gillespie, Sunny Himansu, Alexandra Schäfer, Cynthia T. Ziwawo, Anthony DiPiazza, Kenneth H. Dinnon, Sayda M. Elbashir, Christine A. Shaw, Angela Woods, Ethan J. Fritch, David R. Martinez, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Geoffrey B. Hutchinson, Kapil Bahl, Dario Garcia-Dominguez, LingZhi Ma, Isabella Renzi, Wing‐Pui Kong, Stephen D. Schmidt, Lingshu Wang, Yi Zhang, Laura J. Stevens, Emily Phung, Lauren A. Chang, Rebecca J. Loomis, Nedim Emil Altaras, Elisabeth Narayanan, Mihir Metkar, Vladimir Presnyak, Catherine Liu, Mark K. Louder, Wei Shi, Kwanyee Leung, Eun Sung Yang, Ande West, Kendra L. Gully, Nianshuang Wang, Daniel Wrapp, Nicole A. Doria‐Rose, Guillaume B. E. Stewart-Jones, Hamilton Bennett, Martha Nason, Tracy J. Ruckwardt, Jason S. McLellan, Mark R. Denison, James D. Chappell, Ian N. Moore, Kaitlyn M. Morabito, John R. Mascola, Ralph S. Baric, Andrea Carfı́, Barney S. Graham   +58 more
openalex   +1 more source

Chemically Synthesized LRAD3‐D1 Interacts with N‐Terminal Domain of SARS‐CoV‐2 Spike Protein

ChemBioChem, EarlyView.
Chemical synthesis, calcium‐templated in‐vitro folding and competitive ELISA assay reveal that only domain 1 of the LRAD3 ectodomain interacts with the severe acute respiratory syndrome‐related corona virus 2 (SARS‐CoV‐2) spike NTD, while domains 2 and 3 do not, providing valuable insight into ACE2‐independent viral entry pathways that may contribute ...
Mrinmoy Jana, Rathina Delipan, Arighna Sarkar, Sreejith Raran‐Kurussi, Rajesh P. Ringe, Kalyaneswar Mandal   +5 more
wiley   +1 more source

Intrafamilial Exposure to SARS-CoV-2 Induces Cellular Immune Response without Seroconversion

, 2020
Floriane Gallais, Aurélie Velay, Marie-Josée Wendling, Charlotte Nazon, Marialuisa Partisani, Jean Sibilia, Sophie Candon, Samira Fafi‐Kremer   +7 more
openalex   +1 more source

Pay attention to SARS‐CoV‐2 infection in children

Pediatric Investigation, 2020
Zhengde Xie
doaj   +1 more source

Investigating the Interplay of SARS-CoV-2 RNAemia and Peripheral Inflammation in Platelet Dysfunction During Acute SARS-CoV-2 Infection. [PDF]

Pathog Immun
Scavone M, Rovito R, Ghali C, Fioretti A, Clerici B, Bossi E, Tincati C, Santoro A, Borghi E, Podda GM, Marchetti G.   +10 more
europepmc   +1 more source

Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications

ChemBioChem, EarlyView.
Glycosaminoglycans (GAGs) are linear, anionic biopolymers with their functions tightly linked to their charge. This review approaches GAGs from a polyelectrolyte perspective, shedding light on how the distribution of sulfate groups and, thus, negative charges, governs their interactions with other biomolecules.
Gergo Peter Szekeres, Eunjin Moon, Johanna K. Elter, Bryce Roper, Jayachandran Narayanan Nair Kizhakkedathu, Matthias Ballauff, Rainer Haag, Kevin Pagel   +7 more
wiley   +1 more source

SARS-CoV-2-derived RNA replicons as safe and effective vaccines. [PDF]

Proc Natl Acad Sci U S A
Villarejo-Torres M, Nombela-Diaz I, Muñóz-Santos D, Ruiz-Yuste M, Marchena-Pasero A, Rueda-Huélamo MA, Ripoll-Gómez J, Sánchez-Cordón PJ, Fernandez Del Ama L, Honrubia JM, Gutiérrez-Álvarez J, Hurtado-Tamayo J, Requena-Platek R, Guzmán M, Casasnovas JM, García-Arriaza JF, Perez P, Martin-Jouve B, Matamoros T, Pintado B, Perlman S, Sola I, Zuñiga S, Enjuanes L.   +23 more
europepmc   +1 more source

Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research

ChemBioChem, EarlyView.
The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley   +1 more source

SARS-CoV-2 mutant spectrum complexity is an epidemiologically evolvable trait. [PDF]

Proc Natl Acad Sci U S A
Martínez-González B, Soria ME, de Ávila AI, Somovilla P, Aguilar-Sabido C, Mínguez P, Ferrer-Orta C, Salar-Vidal L, Lorenzo-Redondo R, Delgado S, Morán F, Verdaguer N, Gadea I, Domingo E, Perales C.   +14 more
europepmc   +1 more source