Results 281 to 290 of about 1,228,387 (374)

Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models

Animal Models and Experimental Medicine, EarlyView.
We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv, Ming Liu, Feifei Qi, Mingya Liu, Fengdi Li, Ran Deng, Xujian Liang, Yanfeng Xu, Zhiqi Song, Yiwei Yan, Shuyue Li, Guocui Mou, Linlin Bao   +12 more
wiley   +1 more source

Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry

Angewandte Chemie, EarlyView.
This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou, Chenbo Sun, Weitao Chen, Hanyu Gao, Fei Sun   +4 more
wiley   +2 more sources

SARS-CoV-2 and neurotropism: evidence, gaps and reflections. [PDF]

J Med Microbiol
Lopes TRR, Sitton BS, Pillat MM, Mello CF, Weiblen R, Flores EF, Silva Júnior JVJ.   +6 more
europepmc   +1 more source

Long‐Circulating Nanobody Confers Durable Prophylaxis against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Infection

Advanced NanoBiomed Research, EarlyView.
This study explores Fc engineering to extend nanobody half‐lives in vivo. Herein, it is demonstrated that the circulation half‐life of Nanosota‐3A‐Fc, a novel nanobody with potent neutralizing activity against SARS‐CoV‐2 Omicron BA.1 variant, can be greatly prolonged by introducing M252Y/S254T/T256E (YTE) substitutions in the IgG1 Fc domain, which ...
Geetha Jyothi Vaskuri, Gang Ye, Fan Bu, Dong Yang, Colleen B. Jonsson, Hailey Turner‐Hubbard, Sydney Winecke, Alise Mendoza, Fang Li, Chalet Tan   +9 more
wiley   +1 more source

SARS-CoV-2 in Asthmatic Children: Same Consequences in Different Endotypes? [PDF]

Metabolites
Bosco A, Fanos V, Bosone S, Incandela V, La Ciacera F, Dessì A.   +5 more
europepmc   +1 more source

Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China

The Lancet Oncology, 2020
W. Liang, W. Guan, Ruchong Chen, Wei Wang, Jianfu Li, Ke Xu, Caichen Li, Qing Ai, Weixiang Lu, Hengrui Liang, Shiyue Li, Jianxing He   +11 more
semanticscholar   +1 more source

Markierungsfreie Detektion von Virus‐Membran‐Wechselwirkungen mittels oberflächenverstärkter Infrarot‐Absorptionsspektroskopie (SEIRA)

Angewandte Chemie, EarlyView.
Die virale Bindung und Fusion stellen frühe Schritte in der Virusinfektion dar. Die oberflächenverstärkte Infrarotabsorptionsspektroskopie ermöglicht die markierungsfreie Beobachtung molekularer Prozesse während der Interaktion des Influenza‐A‐Virus mit einem Wirtszellmembranmodell und liefert chemische Auflösung zur Unterscheidung viraler Proteine ...
Amelie Teresa Heinen, Saskia Heermant, Daniel Christian Lauster, Stephan Block, Jacek Kozuch   +4 more
wiley   +1 more source

Evidence for fomite transmission of SARS-CoV-2 Omicron variant in a mouse model. [PDF]

mLife
Yang S, Cao L, Li K, Xu T, Yang Z, Ji Y, Liu L, Zheng B, Ke C, Peng X, Peng H, Guo D, Li CM.   +12 more
europepmc   +1 more source

The association between ABO blood group and SARS-CoV-2 infection: A meta-analysis

, 2020
Davide Golinelli, Erik Boetto, Elisa Maietti, Maria Pia Fantini   +3 more
openalex   +2 more sources

Die Umlenkung der Peptidspaltung führt zur Protease‐Inaktivierung

Angewandte Chemie, EarlyView.
Cysteinproteasen katalysieren die Substratspaltung im Zuge eines zweistufigen Acyltransfers. Die neuartigen peptidischen Inhibitoren von humanem Cathepsin B mit einer N‐terminalen Carbamat‐Kopfgruppe erfahren eine Umlenkung der Peptidspaltung und bilden nicht‐kanonische kovalente Komplexe.
Christian Breuer, Jim Küppers, Anna‐Christina Schulz‐Fincke, Anna Heilos, Carina Lemke, Petra Spiwoková, Janina Schmitz, Laura Cremer, Marta Frigolé‐Vivas, Michael Lülsdorff, Matthias D. Mertens, Filip Wichterle, Miloš Apeltauer, Martin Horn, Erik Gilberg, Norbert Furtmann, Jürgen Bajorath, Ulrike Bartz, Bernd Engels, Michael Mareš, Michael Gütschow   +20 more
wiley   +1 more source