Results 321 to 330 of about 1,228,387 (374)

EudraVigilance insights: Suspected adverse drug reactions in infants through breastfeeding

British Journal of Clinical Pharmacology, EarlyView.
Aims We aimed to describe suspected adverse drug reactions (ADRs) in infants resulting from medications transmitted through mothers' milk, as reported to the European ADR database, EudraVigilance. The research sought to understand the frequency, seriousness and nature of these ADRs to assess potential risks associated with maternal medication use ...
Ida M. Heerfordt, Ditte Resendal Gotfredsen, Henrik Horwitz, Anette Kirstine Stark, Jon Trærup Andersen, Christina Gade, Ulrik Lausten‐Thomsen, Rasmus Huan Olsen   +7 more
wiley   +1 more source

A Systematic Review of Prolonged SARS-CoV-2 Shedding in Immunocompromised Persons. [PDF]

Influenza Other Respir Viruses
Christofferson RC, Giovanni JE, Koumans EH, Ategbole M, Clark SD, Godfred-Cato S, Menon MP, Sastalla I, Schweitzer BK, Uyeki TM.   +9 more
europepmc   +1 more source

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

A Critical Reexamination of Recovered SARS-CoV-2 Sequencing Data. [PDF]

Mol Biol Evol
Débarre F, Hensel Z.
europepmc   +1 more source

Balancing Doses of EL222 and Light Improves Optogenetic Induction of Protein Production in Komagataella phaffii

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Komagataella phaffii, also known as Pichia pastoris, is a powerful host for recombinant protein production, in part due to its exceptionally strong and tightly controlled PAOX1 promoter. Most K. phaffii bioprocesses for recombinant protein production rely on PAOX1 to achieve dynamic control in two‐phase processes.
Shannon M. Hoffman, Sebastián Espinel‐Ríos, Sarah K. Kwartler, Makoto A. Lalwani, José L. Avalos   +4 more
wiley   +1 more source

Dynamic protein interactions probed by NMR spectroscopy

Bulletin of the Korean Chemical Society, EarlyView.
Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley   +1 more source

Enhancing the performance of an in vitro RNA biosensor through iterative design of experiments

Biotechnology Progress, EarlyView.
Abstract The quality control of RNA has become increasingly crucial with the rise of mRNA‐based vaccines and therapeutics. However, conventional methods such as LC–MS often require specialized equipment and expertise, limiting their applicability to high throughput experiments.
Rochelle Aw, Karen Polizzi
wiley   +1 more source

Animal Welfare as an Essential Element of One Health

Animal Research and One Health, EarlyView.
Philip Lymbery
wiley   +1 more source

A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS‐CoV‐2 spike protein production as a vaccine antigen

Biotechnology Progress, EarlyView.
Abstract Fed‐batch recombinant therapeutic protein (RTP) production processes utilizing Chinese Hamster Ovary (CHO) cells can take a long period of time (>10 days). Within this period, not all critical features may be measured routinely, and in fact, some are only measured once the process is terminated, complicating decision making.
Sebastian‐Juan Reyes, Robert Voyer, Yves Durocher, Olivier Henry, Phuong Lan Pham   +4 more
wiley   +1 more source

Practical Challenges in the Diagnosis of SARS-CoV-2 Infection in Children. [PDF]

Nurs Rep
Bouari-Coblișan AP, Pop CF, Sas V, Borcău AG, Bonci TI, Cherecheș-Panța P.   +5 more
europepmc   +1 more source