Results 81 to 90 of about 869,733 (343)

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

New England Journal of Medicine, 2020
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine.
L. Jackson, E. Anderson, N. Rouphael, P. Roberts, M. Makhene, R. Coler, M. P. McCullough, J. Chappell, M. Denison, Laura J. Stevens, A. Pruijssers, A. McDermott, B. Flach, N. Doria-Rose, Kizzmekia S. Corbett, Kaitlyn M. Morabito, S. O'dell, S. Schmidt, P. Swanson, M. Padilla, J. Mascola, K. Neuzil, H. Bennett, Wellington Sun, E. Peters, M. Makowski, J. Albert, Kaitlyn A. Cross, Wendy L. Buchanan, Rhonda Pikaart-Tautges, J. Ledgerwood, B. Graham, J. Beigel   +32 more
semanticscholar   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Post-Coronavirus Disease 2019 Effects in an Active University Population: A Within-Campus Cross-Sectional Study at a Major Educational Institution

Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Objective: To evaluate the associations among post-coronavirus disease 2019 (COVID-19) prevalence; risk factors and comorbidities have not been firmly established within a university outpatient population.
Marcelo Hernández-Mora, MD, René Arredondo-Hernández, PhD, Carmen A. Castañeda-Camacho, MD, Pamela X. Cervantes-Gutierrez, MD, Gonzalo Castillo-Rojas, PhD, Samuel Ponce de León, MD, Yolanda López-Vidal, PhD   +6 more
doaj   +1 more source

Human neutralising antibodies elicited by SARS‐CoV‐2 non‐D614G variants offer cross‐protection against the SARS‐CoV‐2 D614G variant

Clinical & Translational Immunology, 2021
Objectives The emergence of a SARS‐CoV‐2 variant with a point mutation in the spike (S) protein, D614G, has taken precedence over the original Wuhan isolate by May 2020.
Cheryl Yi‐Pin Lee, Siti Naqiah Amrun, Rhonda Sin‐Ling Chee, Yun Shan Goh, Tze‐Minn Mak, Sophie Octavia, Nicholas Kim‐Wah Yeo, Zi Wei Chang, Matthew Zirui Tay, Anthony Torres‐Ruesta, Guillaume Carissimo, Chek Meng Poh, Siew‐Wai Fong, Wang Bei, Sandy Lee, Barnaby Edward Young, Seow‐Yen Tan, Yee‐Sin Leo, David C Lye, Raymond TP Lin, Sebastien Maurer‐Stroh, Bernett Lee, Cheng‐I Wang, Laurent Renia, Lisa FP Ng   +24 more
doaj   +1 more source

The Architecture of SARS-CoV-2 Transcriptome [PDF]

Cell, 2020
SummarySARS-CoV-2 is a betacoronavirus that is responsible for the COVID-19 pandemic. The genome of SARS-CoV-2 was reported recently, but its transcriptomic architecture is unknown. Utilizing two complementary sequencing techniques, we here present a high-resolution map of the SARS-CoV-2 transcriptome and epitranscriptome. DNA nanoball sequencing shows
Kim, Dongwan, Lee, Joo-Yeon, Yang, Jeong-Sun, Kim, Jun Won, Kim, V. Narry, Chang, Hyeshik   +5 more
openaire   +4 more sources

Detection of a SARS-CoV-2 variant of concern in South Africa

Nature, 2021
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2.
H. Tegally, E. Wilkinson, M. Giovanetti, A. Iranzadeh, V. Fonseca, J. Giandhari, D. Doolabh, S. Pillay, E. J. San, N. Msomi, K. Mlisana, A. von Gottberg, S. Walaza, Mushal Allam, A. Ismail, T. Mohale, A. Glass, S. Engelbrecht, G. V. Van Zyl, W. Preiser, Francesco Petruccione, A. Sigal, D. Hardie, G. Marais, N. Hsiao, S. Korsman, M. Davies, L. Tyers, I. Mudau, Denis York, C. Maslo, D. Goedhals, S. Abrahams, O. Laguda-Akingba, A. Alisoltani-Dehkordi, A. Godzik, C. K. Wibmer, B. Sewell, J. Lourenço, L. Alcântara, S. K. Kosakovsky Pond, S. Weaver, D. Martin, R. Lessells, J. Bhiman, C. Williamson, Tulio de Oliveira   +46 more
semanticscholar   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

On the SARS-CoV-2 Variants

Infectious Disease Reports
The evolutionary dynamics of viruses, particularly exemplified by SARS-CoV-2 during the ongoing COVID-19 pandemic, underscore the intricate interplay between genetics, host adaptation, and viral spread. This paper delves into the genetic evolution of SARS-CoV-2, emphasizing the implications of viral variants on global health.
Fabio Scarpa, Francesco Branda, Nicola Petrosillo, Massimo Ciccozzi   +3 more
openaire   +3 more sources

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Nature, 2021
The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation.
Yunlong Cao, Jing Wang, F. Jian, T. Xiao, Weiliang Song, A. Yisimayi, Weijing Huang, Qian-qian Li, Peng Wang, R. An, Jing Wang, Yao Wang, Xiaowei Niu, Sijie Yang, Huitong Liang, Haiyan Sun, Taojing Li, Yuanling Yu, Qianqian Cui, Shuo Liu, Xiaodong Yang, Shuo Du, Zhiying Zhang, Xiaohua Hao, Fei Shao, R. Jin, Xiangxi Wang, Junyu Xiao, Youchun Wang, X. Xie   +29 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source