Results 81 to 90 of about 24,947,267 (297)

Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus

Frontiers in Immunology
Modified vaccinia virus Ankara (MVA) has been widely tested in clinical trials as recombinant vector vaccine against infectious diseases and cancers in humans and animals.
Diana Diaz-Cánova, Ugo Moens, Annika Brinkmann, Andreas Nitsche, Malachy Ifeanyi Okeke   +4 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV

, 2020
After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections.
Yunlong Wang, Guo, Xiangqian, Xu, Jiabao, Wan Zhu, Jiabao Xu, Shizhe Zhao, Xiangqian Guo, Wang, Yunlong, Zhao, Shizhe, Abdalla, E. Abualgasim, Abualgasim Elgaili Abdalla, Xie, Longxiang, Longxiang Xie, Zhu, Wan, Tieshan Teng, Teng, Tieshan   +15 more
core   +1 more source

Immunosuppression as a Hub for SARS-CoV-2 Mutational Drift

, 2023
The clinical course of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is largely determined by host factors, with a wide range of outcomes.
Tal Patalon, Noam Shomron, Sivan Gazit, Guy Shapira   +3 more
core   +1 more source

Mutations and Evolution of the SARS-CoV-2 Spike Protein [PDF]

, 2022
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis
Michael C. McGee, Zhang, Tianyi, Tianyi Zhang, Yingying Wu, Magazine, Nicholas, Wu, Yingying, Weishan Huang, Gianluca Veggiani, Veggiani, Gianluca, Nicholas Magazine, Huang, Weishan, McGee, Michael C.   +11 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Follow-up SARS-CoV-2 serological study of a health care worker cohort following COVID-19 booster vaccination

BMC Infectious Diseases
Background Studies have shown that Omicron breakthrough infections can occur at higher SARS-CoV-2 antibody levels compared to previous variants. Estimating the magnitude of immunological protection induced from COVID-19 vaccination and previous infection
Alexander Hönning, Sara Tomczyk, Julia Hermes, Marica Grossegesse, Natalie Hofmann, Janine Michel, Markus Neumann, Andreas Nitsche, Berthold Hoppe, Tim Eckmanns, Hajo Schmidt-Traub, Kristina Zappel   +11 more
doaj   +1 more source

Inhibition of SARS‐CoV‐2‐mediated thromboinflammation by CLEC2.Fc

EMBO Molecular Medicine, 2023
Thromboinflammation is the major cause of morbidity and mortality in COVID‐19 patients, and post‐mortem examination demonstrates the presence of platelet‐rich thrombi and microangiopathy in visceral organs.
Pei‐Shan Sung, Cheng‐Pu Sun, Mi‐Hua Tao, Shie‐Liang Hsieh   +3 more
doaj   +1 more source

Variants of SARS-CoV-2 [PDF]

JAMA, 2021
Adam S, Lauring, Preeti N, Malani
openaire   +2 more sources

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source