Results 151 to 160 of about 636,460 (260)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virus. [PDF]

Elife
Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Heine H, Qian S, Yang J, Pekosz A, Zhang Y, Wang J.   +11 more
europepmc   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Epigenetic ageing during the COVID-19 pandemic: global age acceleration, independent of SARS-CoV-2 infection. [PDF]

Clin Epigenetics
Shore CJ, Österdahl MF, Harvey NR, Zhao N, Kristiansen M, Michaud DS, Steves CJ, Bell JT, Duncan EL.   +8 more
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Monitoring viral evolution and epidemiological characteristics of SARS-CoV-2 during 2022-2023 using Integrated Genomic Surveillance. [PDF]

Commun Med (Lond)
Mache C, Kerber R, Schulze J, Lataretu M, Abunijela S, Seyam Y, Paraskevopoulou S, Oh DY, Arlt M, Radonić A, Sedaghatjoo S, Budt M, Lehfeld AS, Hartkopf F, Dürrwald R, Semmler T, Haas W, Fuchs S, Kröger S, Wolff T, Integrated Molecular Surveillance for SARS-CoV-2 (IMSSC2) Laboratory Network.   +20 more
europepmc   +1 more source

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

Advanced Science, EarlyView.
This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang, Junteng Qiu, Yunfeng Lu, Yahui Song, Xinyu Zhou, Tianshun Duan, Xuanqi Peng, Caixia Yin, Cheng Gao, Ruibing Wang   +9 more
wiley   +1 more source

Deep learning-assisted, pathogenesis-informed lung histopathology scoring in preclinical mouse models of SARS-CoV-2 and influenza A infection. [PDF]

Front Immunol
An HW, Kim HA, Ha TH, Seok SH, Lee YJ, Lee NY, Yoon GM, Choi YK, Lee HY, Yoo WG, Seong JK, Park JW.   +11 more
europepmc   +1 more source

Sulfur‑Containing Additives for Enhanced Kinetics and Interfacial Stability of Phosphorus Anodes in Li‑Ion Batteries

Advanced Science, EarlyView.
A novel synergistic strategy by employing dual functional sulfur‐containing additives of lithium sulfide (Li2S) and its oxidation product lithium sulfate (Li2SO4) was proposed. Li2SO4 absorbs the solvent molecules to direct the formation of a uniform, Li2O‐rich, and adaptive interphase, which accommodates volume expansion and suppresses parasitic ...
Huixian Xie, Xinze Li, Zhenjiang Yu, Hongyi Chen, Lingwen Liu, Kwun Nam Hui   +5 more
wiley   +1 more source

[SARS]. [PDF]

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2005
openaire   +3 more sources