Results 181 to 190 of about 636,460 (260)

Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness, and pathogenesis of SARS-CoV-2. [PDF]

mBio
Anderson-Daniels J, Diefenbacher MV, Yount BL, Meganck RM, Tse LV, Burke KN, Miranda HA, Scobey DT, Lu X, Stevens L, Dinnon KH, Chapman NS, Pajon C, Powers JM, Nguyen C, Graham RL, Heaton NS, Baric RS, Denison MR, Sheahan TP.   +19 more
europepmc   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Clinical Outcomes and Risk Factors of Healthcare-Associated Infections in Surgical Wards: A Retrospective Cohort Study. [PDF]

Medicina (Kaunas)
Sandu AM, Vrancianu CO, Necula M, Cristian RE, Tantu AC, Păunescu A, Diaconescu D, Tantu MM.   +7 more
europepmc   +1 more source

SARS

International Journal of Super Species Research, 2020
openaire   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

The epidemiology of SARS-CoV-2, Influenza, and Respiratory Syncytial Virus circulation among adult patients with acute respiratory illness in Kampala Metropolitan Area in Uganda. [PDF]

PLoS One
Arinaitwe J, Bakamutumaho B, Mugenyi L, Kiwanuka N, Alupo P, Kawuma AN, Ndahura K, Sekimpi M, Akurut E, Muttamba W, Joloba M, Ocan M, Wampande E, Kyosiimire Lugemwa J, Nakibuuka J, Lusiba J, Okia J, Owachi D, Byakika-Kibwika P, Kirenga B.   +19 more
europepmc   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Comparative Evaluation of SARS-CoV-2 RNA Concentration and Normalization Strategies in Prison Wastewater: Implications for Viral Dynamics in Confined Environments. [PDF]

Viruses
Nazakat R, Mahdzar NA, Azwan AH, Letchumanan R, Rashid SA.   +4 more
europepmc   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source