Results 261 to 270 of about 1,320,827 (304)

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

Advanced Science, EarlyView.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal, Zilong Liu, Meera G. Nair, Juhong Chen   +3 more
wiley   +1 more source

Shift in Demographic Involvement and Clinical Characteristics of COVID-19 From Wild-Type SARS-CoV-2 to the Delta Variant in the Indian Population: In Silico Analysis

Ashutosh Kumar, Adil Asghar, Khursheed Raza, Ravi Kant Narayan, Rakesh Kumar Jha, Abhigyan Satyam, Gopichand Kumar, Prakhar Dwivedi, Chetan Sahni, Chiman Kumari, Maheswari Kulandhasamy, Rohini Motwani, Gurjot Kaur, Hare Krishna, Sujeet Kumar, Kishore Sesham, Sada N. Pandey, Rakesh Parashar, Kamla Kant   +18 more
openalex   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Particulate matter exposure potentiates SARS-CoV-2 delta variant infection by suppressing epithelial antiviral responses. [PDF]

Front Cell Infect Microbiol
Kongsomros S, Paha J, Prasara-A P, Visamol S, Techapichetvanich P, Jiso A, Uppakara K, Morrow AL, Thorman AW, Chutipongtanate S, Khemawoot P, Thitithanyanont A.   +11 more
europepmc   +1 more source

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase. [PDF]

RSC Med Chem
Georgiou I, Robinson C, O'Byrne SN, Matsuda A, Grygier P, Smith CD, O'Neill S, Ahmad SA, Norval S, Post JM, Groenewold M, Urakova N, Wanningen P, Kresik L, Plewka J, Delpal A, See K, Eadsforth T, Wierzbicka K, Decroly E, Saikatendu KS, Chang E, Snijder EJ, Pyrć K, Czarna A, Scott DE, Gilbert IH.   +26 more
europepmc   +1 more source

Molecular analysis of long COVID and new-onset diabetes mellitus: pathobiological relationships and current mechanistic views. [PDF]

Front Endocrinol (Lausanne)
Shitaye G, Getie M, Mekonnen Z, D'Abrosca G, Fattorusso R, Isernia C, Amuamuta A, Malgieri G.   +7 more
europepmc   +1 more source

Predictive markers of SARS-CoV-2 spike-specific cytotoxic T cell activity following Omicron breakthrough infection. [PDF]

Emerg Microbes Infect
Holder KA, Ings DP, Hatfield KM, Fifield KE, Barnes DA, Barnable KA, Harnum DOA, Grant MD.   +7 more
europepmc   +1 more source