Results 211 to 220 of about 25,096,578 (256)

SARS-CoV-2 ORF8: an accessory protein at the interface of immune evasion and inflammation. [PDF]

Front Immunol
Schäfer C, Blamey C, Balbiano R, Mena J, Acuña-Castillo C, Sandino AM.   +5 more
europepmc   +1 more source

Aphasic status epilepticus due to Epstein–Barr virus meningoencephalitis – A clinical vignette

Epileptic Disorders, EarlyView.
Gemma Bassani, Tobias Moser, Lukas Machegger, Fabio Rossini, Georg Pilz, Eugen Trinka, Giorgi Kuchukhidze   +6 more
wiley   +1 more source

Deciphering transcriptome complexity via long‐read sequencing

iMeta, EarlyView.
Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu, Jia Li, Chenxi Yin, Keying Li, Tian Wang, Shiwen Gao, Yue Yu, Cheng Chang, Ye Wang, Guoqing Tong, Liang Gong, Wen Hu, Guoliang Chai, Yilai Han, Qian Qin, Suoqin Jin, Xiufen Zou, Bo Li, Tianyuan Zhang, Ana Conesa, Yunhao Wang, Dingjie Wang   +21 more
wiley   +1 more source

Structure-Based Adaptation of a SARS-CoV-2 Neutralizing Peptide to New Virus Variants. [PDF]

J Med Chem
Raasch N, Weißenborn L, Richel E, Schäfer S, Denysenko O, Bartelsen N, Sticht H, Überla K, Eichler J.   +8 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Discovery of Novel SARS-CoV-2 Fusion Inhibitors-Posaconazole-Polyarginine Conjugates. [PDF]

Viruses
Jin Y, Qu L, Gao X, Qi X, Zhao D, Ga L, Zhao Y, Liang G, Xiao Y, Ma Y.   +9 more
europepmc   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection. [PDF]

Immunity
Yuan D, Li S, Zhang R, Ng RH, Su Y, Lan L, Shome M, Smith B, Troisch P, Xie J, Choi J, Edmark R, Chen D, Rowen L, Nguyen A, Liu R, Gutierrez V, Brennan C, McKasson M, Murray K, Wallick JA, Algren HA, Duven A, Piening B, Thomas W, Kueh HY, Magis AT, Hadlock J, Snyder M, Goldman JD, Heath JR.   +30 more
europepmc   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Serine ubiquitination of the SARS-CoV-2 RdRp by the non-canonical E3 ligase MYCBP2. [PDF]

mSphere
Boytz R, Layne J, Skerrit-Genelus C, Ye C, Hsu JC-C, Martinez-Sobrido L, Laurent-Rolle M.   +6 more
europepmc   +1 more source