Results 171 to 180 of about 24,946,579 (254)

Protein‐Independent Liquid–Liquid Phase Separation of Adenosine Triphosphate Under Crowded Conditions

Chemistry – A European Journal, EarlyView.
ATP itself is able to undergo liquid–liquid phase separation in the presence of the macromolecular crowding agent PEG and physiological ATP concentrations are sufficient for phase separation in the presence of mM Mg2+ and crowders, mimicking intracellular conditions.
Robert Dec, Wojciech Dzwolak, Roland Winter   +2 more
wiley   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Pay attention to SARS‐CoV‐2 infection in children

Pediatric Investigation, 2020
Zhengde Xie
doaj   +1 more source

Exploring novel isatin derivatives as SARS-CoV-2 3CL^pro inhibitors. [PDF]

J Enzyme Inhib Med Chem
Song J, Shi C, Yang B, Yang J, Huang C, Liu J, Wu S, Mo S, Yang J.   +8 more
europepmc   +1 more source

4′‐ThioRNA Substitution and Sense‐Strand Segmentation for the Design of Functional Fully Modified siRNAs Targeting SARS‐CoV‐2

Chemistry – A European Journal, EarlyView.
4′‐ThioRNA was broadly tolerated across multiple positions in SARS‐CoV‐2‐targeting siRNAs, but full 4'‐thio modification of both strands caused a reduction in RNAi activity. Sense‐strand segmentation improved RNAi and antiviral activity, particularly when the nick was located at position 10 from the 5′‐end of the sense strand, thereby unlocking the ...
Yuhei Nogi, Jun Tsukimoto, Noriko Saito‐Tarashima, Takaaki Koma, Masako Nomaguchi, Noriaki Minakawa   +5 more
wiley   +1 more source

Cobalt(III)-Schiff Base Coordination to Nsp1, a SARS-CoV-2 Protein. [PDF]

Inorg Chem
Morales M, Yang MY, Goddard WA, Gray HB, Winkler JR.   +4 more
europepmc   +1 more source

From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems

Chemistry – A European Journal, EarlyView.
This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui, Tianlu Wang, Yaoyu Han, Yun Huang, Tien‐Hung Lan, Yunbin Zhou   +5 more
wiley   +1 more source

Children's Birthday Gatherings and SARS-CoV-2 Infection in Grandparents.

JAMA Netw Open
Espenhain L, Mortensen LH, Christiansen LE, Hansen CH, Ethelberg S.   +4 more
europepmc   +1 more source

Serological Predictors of Protection from Infection Upon Household Exposure to SARS-CoV-2. [PDF]

Eur J Immunol
Maaß H, Hinrichs I, Pavletic M, Harries M, Prinke T, Bdeir N, Egelkamp R, Lange B, Bartsch YC, Lerga M, Cicin-Sain L.   +10 more
europepmc   +1 more source

Formation of Lanthanide Luminescent Aggregates With RNA Using Tripodal Europium [Eu(III)] BTA Self‐Assembled Complexes

Chemistry – A European Journal, EarlyView.
The two Eu(III) complexes of 1.Eu and 2.Eu, that were formed in situ, were used to bind to yeast RNA and A10 (RNA) in a buffered pH 7 solution. The interaction gave rise to changes in the lanthanide‐centered emission because of direct binding of these complexes, which resulted in aggregation of the RNA, as demonstrated using phase‐contrast and atomic ...
Tómas A. Gudmundsson, Changzhuang Bai, Grace E. Maynard, Pall Thordarson, Thorfinnur Gunnlaugsson   +4 more
wiley   +1 more source