Results 271 to 280 of about 2,592,842 (396)

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Assessment of SARS-CoV-2 immune escape using antigenic cartography combined with experimental challenge studies. [PDF]

NPJ Vaccines
Te Marvelde MR, Mykytyn AZ, Veldhuis Kroeze EJB, Bouffier AHJ, van Eck-Schipper D, van den Doel P, Handrejk K, Koel B, Rissmann M, Haagmans BL.   +9 more
europepmc   +1 more source

Have SARS-CoV-2 virus (COVID-19) lockdown restrictions impacted the prevalence and severity of retinopathy of prematurity in a London population?

, 2021
Shehnaz Bazeer, Ashwin Mahtani, Ambalika Das, Ayman Khaier, Marcus Posner   +4 more
openalex   +1 more source

Olfactory Dysfunction and Cognitive Deterioration in Long COVID: Pathomechanisms and Clinical Implications in Development of Alzheimer's Disease. [PDF]

Cells
Stigliano E, Tocci A, Florio R, Arena V, Amadoro G.   +4 more
europepmc   +1 more source

Advances in Double‐Stranded DNA Targeting Technologies

Exploration, EarlyView.
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen, Yiqun Liu, Yingjie Hao, Yifan Bo, Xiaochuan Dai, Shihui Wang, Tian Xia, Xin Su, Huiyu Liu   +8 more
wiley   +1 more source

A One-Year Wastewater-Based Surveillance Study of the Main Human Respiratory Viruses in a Middle-Size Spanish City During the COVID-19 Pandemic Period. [PDF]

Microorganisms
Casado-Martín L, Hernández M, González-Peña MJ, Alves-Elois M, Yeramian N, Fongaro G, Eiros JM, Rodríguez-Lázaro D.   +7 more
europepmc   +1 more source

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

Food Bioengineering, EarlyView.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob, Gebremedhin Gebreslassie, Etsay Mesele, Tesfakiros Semere   +3 more
wiley   +1 more source

Developing Synthetic Full-Length SARS-CoV-2 cDNAs and Reporter Viruses for High-Throughput Antiviral Drug Screening. [PDF]

Viruses
Rohamare M, Kaushik N, Khan JQ, Balouchi M, Lopez-Orozco J, Kozak R, Hobman TC, Falzarano D, Kumar A, Wilson JA.   +9 more
europepmc   +1 more source

Local Responses to Limits on U.S. Public Health Authority During the COVID‐19 Emergency

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Public health has become politicized in the U.S. Though research shows that limiting public health authority during emergency response puts community wellbeing and health outcomes at risk, during the COVID‐19 emergency (2020–2021), some U.S. state policymakers limited the disease‐preventing actions local public health agencies could take. This
Genevive R. Meredith, Xue Zhang, Zachary M. Batterman, Hannah M. Morris, Zhiwei Chen, Mah Liqa, Mildred E. Warner   +6 more
wiley   +1 more source

HEDGES co-prevents both SARS-CoV-2 and pandemic influenza infection in mice by rapid, durable co-production of twelve different anti-pandemic monoclonal antibodies. [PDF]

PLoS One
Mack M, Ye A, Ursu S, Ice R, Soroceanu L, Shoor S, McAllister S, Heath T, Handumrongkul C, Debs R.   +9 more
europepmc   +1 more source