Results 91 to 100 of about 534,212 (263)

A new high-accuracy QSAR model based on ultra-curated data for predicting thyroid receptor-related endocrine activity

Frontiers in Toxicology
IntroductionEndocrine active substances interfere with hormone signalling and represent a major regulatory concern. The thyroid system is particularly vulnerable, with disruption linked to neurodevelopmental, metabolic, and cardiovascular effects ...
Emel Ay-Albrecht, Zlatomir Todorov, Franklin J. Bauer, Marie Darracq-Ghitalla-Ciock, Carole Charmeau-Genevois, Satinder S. Sarang, Paul C. Thomas   +6 more
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Quantifying hope: an EU perspective of rare disease therapeutic space and market dynamics

Frontiers in Public Health
Rare diseases, affecting millions globally, pose a significant healthcare burden despite impacting a small population. While approximately 70% of all rare diseases are genetic and often begin in childhood, diagnosis remains slow and only 5% have approved
Emmanuelle Cacoub, Emmanuelle Cacoub, Nathalie Barreto Lefebvre, Dimitrije Milunov, Manish Sarkar, Soham Saha   +5 more
doaj   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Machine Learning–Guided Surface Strain Engineering in Connected Platinum–Nickel Nanoparticle Catalysts for Advanced Oxygen Reduction Performance

Advanced Science, EarlyView.
Machine learning‐guided strain engineering enables highly active, durable, support‐free Pt–Ni nanonetwork catalysts for the oxygen reduction reaction. Analysis of a Pt‐based catalyst dataset identifies surface compressive strain as an effective descriptor associated with enhanced activity and provided practical design guidelines.
Aparna Chitra Sudheer, Gopinathan M. Anilkumar, Hidenori Kuroki, Yuuki Sugawara, Takeo Yamaguchi   +4 more
wiley   +1 more source

Sas Agapo

The Journal of the Sylvia Townsend Warner Society
An edited presentation of a previously unpublished short story by Sylvia Townsend Warner. A widower’s feelings are stirred by an adder he discovers in his garden. The story is undated but the typewriter suggests a date in the mid- to late 1950s.
doaj   +2 more sources

SAS contract [PDF]

British Dental Journal, 2008
openaire   +2 more sources

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Single‐Atom‐Enhanced Fully Inkjet‐Printed Electrochemical Sensor for Dopamine Detection

Advanced Science, EarlyView.
Fully inkjet‐printed paper‐based dopamine sensors are fabricated using nitrogen‐doped graphene acid functionalized with copper single atoms. The copper sites uniquely enhance dopamine oxidation through strong molecular adsorption, as verified by electrochemical measurements and DFT calculations. The approach highlights the potential of single‐atom inks
Martin‐Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendrišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal Otyepka   +11 more
wiley   +1 more source

Stabilising the Lattice Oxygen Oxidation Mechanism Through Iridium Single Atoms in Chromium‐Doped Cobalt Iron Layered Double Hydroxides

Advanced Science, EarlyView.
Iridium single atoms and Cr doping synergistically activate and stabilise the lattice oxygen oxidation mechanism in CoFe layered double hydroxides. Electronic modulation enhances metal–oxygen covalency, suppresses over‐oxidation, and enables durable oxygen evolution, delivering high‐performance anion exchange membrane water electrolysis with ...
Parisa Eskandari, Shujie Zhou, Jodie Yuwono, Yufei Zhao, Hanyu Xu, Zhihong Tian, Jingwen Ba, Ming Zhang, Bernt Johannessen, Thanh Son Bui, Richard F. Webster, Jing Chu, Xunyu Lu, Rose Amal   +13 more
wiley   +1 more source