British Journal of Clinical Pharmacology, EarlyView.Aim Our international cohort study assessed the comparative effectiveness and safety of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) among patients with non‐valvular atrial fibrillation (NVAF) using antiarrhythmic drugs. Methods Using the United Kingdom's (UK's) Clinical Practice Research Datalink Aurum and Québec claims data, we
Fabian Maximilian Meinert +5 more
wiley +1 more source
Development, Optimization, and Evaluation of Nano Self-Emulsifying Drug Delivery System Formulation Platform for Oral Bioavailability Enhancement of Sulfasalazine and Disulfiram in Lung Cancer Chemoprevention. [PDF]
Pharm ResDesai P +7 more
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo +10 more
wiley +1 more source
Elicitation of protective immune responses against influenza a viruses in elderly ferrets by adjuvanted recombinant universal influenza hemagglutinin vaccines. [PDF]
Immun AgeingZhang X, Shi H, Ross TM.
europepmc +1 more source
A Guide to Bayesian Optimization in Bioprocess Engineering
Biotechnology and Bioengineering, EarlyView.ABSTRACT Bayesian optimization has become widely popular across various experimental sciences due to its favorable attributes: it can handle noisy data, perform well with relatively small data sets, and provide adaptive suggestions for sequential experimentation.
Maximilian Siska +5 more
wiley +1 more source
Predictors of miscarriage in polycystic ovary syndrome patients with threatened abortion: development and validation of a nomogram model. [PDF]
Front Endocrinol (Lausanne)Ma L, Zhou Q.
europepmc +1 more source
Improved Messenger RNA Stability and Biocompatibility Through Self‐Gelatinizable Nucleic Acids
Biotechnology and Bioengineering, EarlyView.ABSTRACT Recent advances in the chemical synthesis and modification of messenger RNA (mRNA) have generated growing interest in mRNA‐based therapeutics. However, the inherent instability of mRNA in vivo and during storage remains a major challenge, requiring the development of safe and effective delivery systems.
Takumi Tanifuji +5 more
wiley +1 more source
Introduction to the special issue related to the 19th International Small Angle Scattering Conference (SAS2024). [PDF]
J Appl CrystallogrJeng US +4 more
europepmc +1 more source
Applied multivariate statistics with SAS software, second edition
Computers & Mathematics with Applications, 1999 openaire +1 more source
Biotechnology Progress, EarlyView.Abstract Red blood cells (RBCs) play a critical role in oxygen and carbon dioxide transport, which is facilitated by RBC‐encapsulated hemoglobin (Hb) and carbonic anhydrase (CA). In addition, RBCs are constantly exposed to oxidative stress due to the intracellular reactive oxygen species (ROS) generated during Hb auto‐oxidation.
Mohd Asim Khan +4 more
wiley +1 more source