Results 221 to 230 of about 574,679 (272)

LCP1 upregulation via EGFR signaling promotes oral cancer progression through the JAK2/STAT3/IL-1β axis. [PDF]

Cancer Cell Int
Liu CR, Yang CY, Chang KP, Chan XY, Hung CM, Lai KM, Liu HP, Wu CC.   +7 more
europepmc   +1 more source

Difference Between Low‐Speed and High‐Speed Rotational Atherectomy Using Two Types of Guidewires

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Debulking devices are necessary to treat severe calcified lesions. Rotational atherectomy (RA) is widely employed to modify calcified plaques, but the influence of procedural variables, such as guidewire type and ablation speed, on ablation outcomes is not well established.
Akito Kawamura, Keita Okayama, Hiroaki Nohara, Tomoaki Nakano, Yasushi Sakata   +4 more
wiley   +1 more source

Negative life events and problematic smartphone use among university students: the mediating role of self-efficacy and the moderating role of physical activity. [PDF]

Front Public Health
Yang C, Huang W, Hu C, Zhang W, Chen B, Zhou C, Zhu D, Xu B.   +7 more
europepmc   +1 more source

Clinical assessment of mocravimod as a victim of drug–drug interactions via CYP3A4 metabolism and transporters

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens, Stephan Oehen, Elisabeth Kueenburg   +2 more
wiley   +1 more source

Janus Mn single atoms for triggering efficient photothermal catalytic CO₂ methanation through spin polarization effect. [PDF]

Sci Adv
Xu Y, Chen S, Yao L, Dai W, Fang J, Sun C, Feng W, Zou J, Luo X.   +8 more
europepmc   +1 more source

Comparative Bioequivalence and Safety Evaluation of Ibuprofen/Phenylephrine Hydrochloride Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This single‐center, randomized, open‐label bioequivalence program compared two fixed‐dose combination (FDC) tablets containing ibuprofen (200 mg) and phenylephrine hydrochloride (10 mg) from different manufacturers in healthy Chinese adults under fasting and fed conditions. A three‐period, partially replicated crossover design was used for the
Menghan Ye, Rui Zhang, Jing Wan, Jinping Zhou, Pengpeng Guo, Dianwen Yu, Peixia Li, Yani Liu, Shaojun Shi   +8 more
wiley   +1 more source

Development of a psychosocial-clinical nomogram to predict delayed medical help-seeking in women with stress urinary incontinence: a retrospective cohort study. [PDF]

Front Med (Lausanne)
Luo X, Zhong Y, Ai D, Yin G, Mo L.
europepmc   +1 more source

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

Validity, reproducibility, and reliability of the Brazilian version of the smartphone addiction scale-short version in children. [PDF]

Rev Paul Pediatr
Martins RV, Bacil EDA, Silva MPD, Campos W.   +3 more
europepmc   +1 more source

Emulating Six Cardiovascular Outcome Trials of Antidiabetic Drugs in Individuals with Type 2 Diabetes: Analyses Based on Real‐World Databases from Korea and Taiwan

Clinical Pharmacology &Therapeutics, EarlyView.
With the increasing volume of clinical evidence derived from large‐scale Asian real‐world data (RWD) and the growing interest in its use in regulatory decision‐making, it is important to conduct benchmarking exercises that evaluate whether studies using Asian RWD can generate similar conclusions as randomized controlled trials (RCTs).
Hwa Yeon Ko, Philip C. M. Au, Michael Chun‐Yuan Cheng, Ching‐Lung Cheung, Ahhyung Choi, Miyuki Hsing‐Chun Hsieh, Han Eol Jeong, Edward Chia‐Cheng Lai, Brian Meng‐Hsun Li, Kenneth K. C. Man, Jeremy A. Rassen, Daniel Hsiang‐Te Tsai, Shirley V. Wang, Ian C. K. Wong, Ju‐Young Shin, Sohee Park   +15 more
wiley   +1 more source