Results 41 to 50 of about 574,034 (286)

Sas-temper: Software for fitting small-angle scattering data that provides automated reproducibility characterization

SoftwareX, 2021
The analysis of small-angle X-ray and neutron scattering data is both time-consuming and fraught with the challenges intrinsic to non-linear least squares minimization processes.
William T. Heller, Mathieu Doucet, Richard K. Archibald   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Distributed Regression Analysis Application in Large Distributed Data Networks: Analysis of Precision and Operational Performance

JMIR Medical Informatics, 2020
BackgroundA distributed data network approach combined with distributed regression analysis (DRA) can reduce the risk of disclosing sensitive individual and institutional information in multicenter studies.
Her, Qoua, Malenfant, Jessica, Zhang, Zilu, Vilk, Yury, Young, Jessica, Tabano, David, Hamilton, Jack, Johnson, Ron, Raebel, Marsha, Boudreau, Denise, Toh, Sengwee   +10 more
doaj   +1 more source

Ordinal Regression Analysis: Predicting Mathematics Proficiency Using the Continuation Ratio Model [PDF]

, 2011
One commonly used model to analyze ordinal response data is the proportional odds (PO) model. However, if research interest is focused on a particular category and if an individual must pass through lower categories before achieving a higher level, the ...
Koirala, Hari, Liu, Xing, O\u27Connell, Ann A.   +2 more
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Introduction to medical statistics software using the flipped classroom: a pilot study

Journal of Statistics and Data Science Education, 2022
Teaching practical skills is of particular interest in the study of human medicine. With regard to medical statistics this means the use of statistical software, which may be effectively taught by a flipped classroom approach.
Benjamin Mayer, Anja Kuemmel, Marianne Meule, Rainer Muche   +3 more
doaj   +1 more source

«Інформаційно-комунікаційні технології навчання», 4-та Всеукраїнська науково-практична конференція [PDF]

, 2016
Стаття присвячена опису методики побудови кредитних скорінгових карт із використанням програмного забезпечення SAS Credit Scoring.The article describes methods of constructing credit scoring cards using software SAS Credit Scoring.Статья посвящена ...
Бакун, Сабіна, Литвинюк, Антон, Терентьєв, Олександр   +2 more
core  

Detecting variable responses in time-series using repeated measures ANOVA: Application to physiologic challenges. [PDF]

, 2016
We present an approach to analyzing physiologic timetrends recorded during a stimulus by comparing means at each time point using repeated measures analysis of variance (RMANOVA).
Harper, Ronald M, Macey, Katherine E, Macey, Paul M, Schluter, Philip J   +3 more
core   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source