Results 81 to 90 of about 54,638 (265)

Translation, negation, reflection: On the negative-contradictory nature of translation

open access: yes, 2020
The article aims to examine the relationship between translation, negation, and reflection. Starting with some Saussure’s claims and Paolo Virno’s An Essay on Negation, the article shall bring to light how the negative-differential nature of language ...
Sasa Hrnjez, Hrnjez, Sasa
core   +1 more source

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo   +17 more
wiley   +1 more source

Paramerina okimaculata Sasa

open access: yes, 2008
Paramerina okimaculata Sasa (Figs. 7–8) Paramerina okimaculata Sasa, 1990: 142 –143, Fig. 29. [Holotype 174: 096.] The species keys to Paramerina Fittkau in Murray and Fittkau (1989). Based on the re-examination of the holotype the following characters are added to the original description: tibial spurs stouter than in other Paramerina species, i.e ...
Kobayashi, Tadashi, Endo, Kazuo
openaire   +2 more sources

Characterization of Full‐Length Antibody Complexes Through HDX‐Mass Spectrometry Coupled With NMR Spectroscopy: New Insight Into Avelumab/PD‐L1 Interaction

open access: yesAngewandte Chemie, EarlyView.
Combining HDX‐MS and NMR enables the mapping of epitopes and paratopes in full‐length antibody complexes, revealing transient interactions and potential artifacts. ABSTRACT Recombinant biomacromolecules have significantly transformed pharmaceuticals, in particular monoclonal antibodies (mAbs) that target key areas in oncology, immunology, inflammation,
Francesca Sacco   +13 more
wiley   +2 more sources

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

open access: yesAdvanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang   +8 more
wiley   +1 more source

Solvent accessible surface area (SASA).

open access: yes, 2023
(A). G1 epitope. (B). G2 epitope. (C). H1 epitope. (D). H2 epitope. The blue bars depict the SASA from the epitope in solution. The green bars depict the SASA from the epitope in the MHC.
Edgar Mixcoha (1786729)   +2 more
core   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

open access: yesAdvanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu   +20 more
wiley   +1 more source

Coarse‐Grained Simulations Rationalize Thermosensitivity and Hydrolytic Degradation of Vinyl Copolymers Obtained by Radical Ring‐Opening Polymerization

open access: yesAngewandte Chemie, EarlyView.
Coarse‐grained (CG) molecular dynamics simulations were used to predict the upper critical solution temperature of copolymers obtained by radical ring‐opening copolymerization of cyclic ketene acetals and vinyl monomers, and to account for their unique degradation kinetics under physiological conditions by evaluating the solvation of their ester groups.
Ping Gao   +3 more
wiley   +2 more sources

CLIMATE REGIONALIZATION OF SERBIA ACCORDING TO KÖPPEN CLIMATE CLASSIFICATION

open access: yesZbornik Radova: Geografski institut "Jovan Cvijić", 2017
The paper presents a concise overview of the theoretical framework on which climate classifications are based. Beside short review of climate classifications, namely climatic regionalization for Serbia (or wider area including Serbia), main deficiency of
Boško Milovanović   +3 more
doaj   +1 more source

Tempo e/è concetto. Storia degli effetti di una virgola

open access: yes, 2016
This articles examines the relation between time and concept in Hegel, with an attention to the final pages of Phenomenology of Spirit where the cancellation of time is discussed.
Hrnjez Sasa, Hrnjez, Sasa
core   +1 more source

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