Aziridine-Metathesis based Approaches to Alkaloid Synthesis [PDF]
The aim of the project is to synthesise (-)-morphine utilising aziridine and metathesischemistry. The thesis is divided into three chapters.Chapter 1 provides brief reviews on the subjects of total synthesis of morphine; ringrearrangementmetathesis (RRM)
Lu, Pengfei, Lu, Pengfei
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Improved rotational‐XOR cryptanalysis of Simon‐like block ciphers
Rotational‐XOR (RX) cryptanalysis is a cryptanalytic method aimed at finding distinguishable statistical properties in Addition‐Rotation‐XOR‐C ciphers, that is, ciphers that can be described only by using modular addition, cyclic rotation, XOR and the ...
Jinyu Lu +4 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
A logic obfuscation attack method based on gate-level information flow tracing techniques
Logical obfuscation technique is a mainstream technical means to achieve intellectual property protection and prevent reverse engineering. In this paper, we propose a logical obfuscation attack method based on the gate-level information flow tracking ...
LIU Liang +5 more
doaj +1 more source
Cryptanalysis of Reduced-Round SPECK
SPECK, a family of lightweight block ciphers proposed by the National Security Agency (NSA), is widely used under resource constrained environment. There are many cryptanalytic results on SPECK concentrated on differential and linear attacks.
Jiongjiong Ren, Shaozhen Chen
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
Quantum Algorithms for Boolean Equation Solving and Quantum Algebraic Attack on Cryptosystems [PDF]
Decision of whether a Boolean equation system has a solution is an NPC problem and finding a solution is NP hard. In this paper, we present a quantum algorithm to decide whether a Boolean equation system FS has a solution and compute one if FS does have ...
Chen, Yu-Ao, Gao, Xiao-Shan
core +1 more source

