The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer
Advanced Science, EarlyView.In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu +16 more
wiley +1 more source
Advanced Science, EarlyView.Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang +12 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen +4 more
wiley +1 more source
Principles for Rigorous Design and Application of Synthetic Microbial Communities
Advanced Science, EarlyView.SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang +21 more
wiley +1 more source
RAFF-AMACNet: Adaptive Multi-Rate Atrous Convolution Network with Residual Attentional Feature Fusion for Satellite Signal Recognition. [PDF]
Sensors (Basel)Chen L +6 more
europepmc +1 more source
Super‐Robust Telecommunications Enabled by Topological Half‐Supermodes
Advanced Science, EarlyView.Through topological half‐supermode engineering, we realize a valley‐ridge gap waveguide that is directly compatible with conventional waveguides and features topological protection. This design halves the lateral size via a PEC boundary, enabling direct TE₁₀‐mode matching and robust bend‐immune transmission.
Rui Zhou +8 more
wiley +1 more source
Maximizing Nanosatellite Throughput via Dynamic Scheduling and Distributed Ground Stations. [PDF]
Sensors (Basel)Ronen R, Ben-Moshe B.
europepmc +1 more source
The Microbiota Shapes Central Nervous System Myelination in Early Life
Advanced Science, EarlyView.Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch +13 more
wiley +1 more source
Interference Suppression via Joint Interference Alignment and Power Allocation in Integrated Communication and Navigation Systems. [PDF]
Sensors (Basel)Wang X, He T, Ren X, Jing X.
europepmc +1 more source
Economic aspects of communication satellite systems [PDF]
Meckling, W. H., Reiger, S. H.
core +1 more source