Results 51 to 60 of about 168,834 (300)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Dependence of Cold and Hot Patches on Local Plasma Transport and Particle Precipitation in Northern Hemisphere Winter

Geophysical Research Letters, 2022
By using a database of 4,634 cold patches (high density and low electron temperature) and 4,700 hot patches (high density and high electron temperature) from Defense Meteorological Satellite Program F16 in 2005–2018 winter months (October–March), we ...
Duan Zhang, Qing‐He Zhang, Y.‐Z. Ma, Kjellmar Oksavik, L. R. Lyons, Zan‐Yang Xing, Marc Hairston, Z.‐X. Deng, J.‐J. Liu   +8 more
doaj   +1 more source

Localizing Stellar Activity on Low-mass Stars with the Transiting Exoplanet Survey Satellite

Research Notes of the AAS
Magnetic reconnection is the underlying cause of stellar flares which are linked to regions of high magnetic activity, like star spots. To understand trends in stellar activity, we need to study how it is heightened by rapid rotation and deep convection ...
Julie Moquin, Jordan Ealy, J. Schlieder, C. Johns–Krull   +3 more
semanticscholar   +1 more source

Transpolar voltage and polar cap flux during the substorm cycle and steady convection events [PDF]

, 2009
Transpolar voltages observed during traversals of the polar cap by the Defense Meteorological Satellite Program (DMSP) F-13 spacecraft during 2001 are analyzed using the expanding-contracting polar cap model of ionospheric convection.
Ahn, Ahn, Alexis Rouillard, Boudouridis, Boyle, Bristow, Cai, Chisham, Cowley, Cowley, Cowley, Doyle, Eriksson, Fox, Freeman, Freeman, Freeman, Grocott, Hairston, Hairston, Hairston, Hairston, Hanson, Hapgood, Holzer, Hones, Hubert, Ivan Finch, Khan, Kihn, Kivelson, Lagarias, Lockwood, Lockwood, Lockwood, Lockwood, Lockwood, Lockwood, Lockwood, Lockwood, Lockwood, Lockwood, Lockwood, Lu, Lu, Lu, Marc Hairston, Mike Lockwood, Milan, Milan, Milan, Morley, Mozer, Murphree, Nagatsuma, Nakata, Nelder, Newell, Nishida, Papitashvili, Phan, Provan, Reiff, Reiff, Reiff, Ridley, Ridley, Ruohoniemi, Ruohoniemi, Russell, Shepherd, Siscoe, Siscoe, Siscoe, Sonnerup, Weimer, Weimer, Wygant, Zhang   +78 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Progress and challenges in modeling global lithospheric magnetic anomalies

地球与行星物理论评
Over the past 50 years, extensive airborne and oceanic magnetic survey data collection efforts have resulted in the almost complete coverage of near-surface magnetic survey data worldwide.
Yao Luo, Jingmin Li, Jinxin Zheng, Xue Yang, Hang Yin, Wenzhi Zhang, Qingkui Meng, Bing Li, Linfei Wang   +8 more
doaj   +1 more source

Geomagnetism : review 2010 [PDF]

, 2011
The Geomagnetism team measures, records, models and interprets variations in the Earth’s natural magnetic fields, across the world and over time. Our data and expertise help to develop scientific understanding of the evolution of the solid Earth and ...

core  

How efficient is an integrative approach in archaeological geophysics? Comparative case studies from Neolithic settlements in Thessaly (Central Greece) [PDF]

, 2015
The geophysical prospection of Neolithic tells imposes specific challenges due to the preservation and nature of the architectural context and the multiple, usually disturbed, soil strata.
Cuenca-Garcia, C., Donati, J.C., Kalayci, T., Manataki, M., Sarris, A., Simon, F.-X.   +5 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Preliminary results of the High Energetic Particle Package on-board the China Seismo-Electromagnetic Satellite

Earth and Planetary Physics, 2018
The high energetic particle package (HEPP) on-board the China Seismo-Electromagnetic Satellite (CSES) was launched on February 2, 2018. This package includes three independent detectors: HEPP-H, HEPP-L, and HEPP-X.
Wei Chu, JianPing Huang, XuHui Shen, Ping Wang, XinQiao Li, ZhengHua An, YanBing Xu, XiaoHua Liang   +7 more
doaj   +1 more source