Results 51 to 60 of about 49,302 (339)

Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning

Advanced Science, EarlyView.
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao, Guiyuan Shi, Ruixue Qin, Yinghao Sun, Wenbo Guo, Ruixia Shi, Minxian Peng, Jingxuan Yang, Jianjian Zhao, Qiuhan Liu, Jun Xiao, Ke Zhang, Qiang Liu, Wenxing Yang, He Liu   +14 more
wiley   +1 more source

Temporally and Spatially Distinct Thirst Satiation Signals [PDF]

, 2019
For thirsty animals, fluid intake provides both satiation and pleasure of drinking. How the brain processes these factors is currently unknown. Here, we identified neural circuits underlying thirst satiation and examined their contribution to reward ...
Augustine, Vineet, Ebisu, Haruka, Ho, Brittany, Lee, Sangjun, Mizuno, Grace O., Oka, Yuki, Tian, Lin, Zhao, Yuan   +7 more
core  

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Middle ratings rise regardless of grammatical construction: Testing syntactic variability in a repeated exposure paradigm.

PLoS ONE, 2021
People perceive sentences more favourably after hearing or reading them many times. A prominent approach in linguistic theory argues that these types of exposure effects (satiation effects) show direct evidence of a generative approach to linguistic ...
J M M Brown, Gisbert Fanselow, Rebecca Hall, Reinhold Kliegl   +3 more
doaj   +1 more source

Monosodium glutamate delivered in a protein-rich soup improves subsequent energy compensation [PDF]

, 2014
Previous research suggests that monosodium glutamate (MSG) may have a biphasic effect on appetite, increasing appetite within a meal with its flavour-enhancing effect, but enhancing subsequent satiety due to its proposed role as a predictor of protein ...
Blundell, Geha, Ikeda, Kwok, Niijima, Simpson, Weigle, Williams   +7 more
core   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

A Rat Model of Human Lipid Emulsion Digestion

Frontiers in Nutrition, 2019
A better understanding of how dietary lipids are processed by the human body is necessary to allow for the control of satiation and energy intake by tailored lipid systems.
Andreas Steingoetter, Andreas Steingoetter, Myrtha Arnold, Nathalie Scheuble, Shahana Fedele, Pascal Bertsch, Dian Liu, Helen L. Parker, Helen L. Parker, Helen L. Parker, Wolfgang Langhans, Peter Fischer   +11 more
doaj   +1 more source

The Water Load Test As a Measure of Gastric Interoception: Development of a Two-Stage Protocol and Application to a Healthy Female Population. [PDF]

PLoS ONE, 2016
The sensitivity for one's own internal body signals (i.e., interoception) has been demonstrated to play an important role in the pathogenesis of eating and weight disorders.
Zoé van Dyck, Claus Vögele, Jens Blechert, Annika P C Lutz, André Schulz, Beate M Herbert   +5 more
doaj   +1 more source

Gut throughput rate and satiation of the invasive Lionfish (Pterois volitans) and its potential impact on an endemic, endangered Labrid fish Halichoeres socialis [PDF]

, 2017
The invasive Indo-Pacific Lionfish Pterois volitans has been recognized as a severe threat to indigenous fish species on Caribbean reefs. Previous studies have identified an extensive variety of Caribbean fishes in the stomachs of lionfish, but few have ...
Garner, James Graham
core  

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source