Results 71 to 80 of about 693,962 (268)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Macro-micro mechanical behavior research on gas hydrate bearing coal based on parallel bonding model

Meitan xuebao
Discrete element simulation of triaxial compression test was carried out to study the effects of confining pressure and saturation on the macro and meso mechanical properties of gas hydrate bearing coal (GHBC).
Nannan WANG, Xia GAO, Jizhe ZHANG, Baoyong ZHANG, Qiang WU   +4 more
doaj   +1 more source

Robust ${L_{2}} - {L_{\infty}}$ Filter Design for Uncertain 2-D Continuous Nonlinear Delayed Systems With Saturation

IEEE Access, 2018
This paper discusses the L2 - L∞ filter design problem for non-linear two-dimensional (2-D) uncertain continuous systems with state delays and saturation.
Zhaoxia Duan, Imran Ghous, Jahanzeb Akhtar, Khurram Ali, Mujtaba Hussain Jeffery   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Improving the visualization and detection of tissue folds in whole slide images through color enhancement

Journal of Pathology Informatics, 2010
Objective : The objective of this paper is to improve the visualization and detection of tissue folds, which are prominent among tissue slides, from the pre-scan image of a whole slide image by introducing a color enhancement method that enables the ...
Pinky A Bautista, Yukako Yagi
doaj   +1 more source

Getting Saturated with Induction

, 2022
Induction in saturation-based first-order theorem proving is a new exciting direction in the automation of inductive reasoning. In this paper we survey our work on integrating induction directly into the saturation-based proof search framework of first-order theorem proving.
Márton Hajdú, Petra Hozzová, Laura Kovács, Giles Reger, Andrei Voronkov   +4 more
openaire   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Precise Reflectance/Transmittance Measurements of Highly Reflective Optics with Saturated Cavity Ring-Down Signals

Photonics
In this paper, a data processing approach was developed to accurately extract the ring-down time and amplitude of the saturated cavity ring-down (CRD) signal; both were utilized to determine simultaneously the high reflectance and residual transmittance ...
Yanling Han, Bincheng Li, Jing Wang, Hao Cui, Tianming Wang   +4 more
doaj   +1 more source

Assessment of the colors of the melanin pigment in acral compound nevus by using a novel dermoscopy technique with surgical light illumination and saturation analysis

Dermatology Practical & Conceptual, 2019
Introduction On dermoscopy, the amount and location of melanin pigment can be assessed on the basis of its colors, ranging from black, brown to blue-gray.
Hiroshi Sakai, Kyoko Tonomura, Hirotsugu Shirabe, Masaru Tanaka   +3 more
doaj   +1 more source