Results 101 to 110 of about 693,962 (268)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

Città sature

open access: yes, 2012
Spazio Filosofico, 06 ...
openaire   +2 more sources

Saturation number of nanotubes

open access: yesArs Mathematica Contemporanea, 2017
In the present paper we are interested in the saturation number of closed benzenoid chains and certain families of nanotubes. The saturation number of a graph is the cardinality of a smallest maximal matching in the graph. The problem of determining the saturation number is related to the edge dominating sets and efficient edge dominating sets in a ...
Niko Tratnik, Petra Zigert Pletersek
openaire   +3 more sources

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp   +4 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Analyse d’un générateur autonome alimentant une charge isolée variable reliée à un redresseur commandé

open access: yesRevue des Énergies Renouvelables, 2015
Les systèmes d’énergie renouvelable sont de plus en plus utilisés dans la production de l’énergie électrique. L’intérêt porté à cette solution alternative est dû particulièrement à l’augmentation du prix de l’énergie conventionnelle et le problème de la ...
M. Imadouchene   +3 more
doaj  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Measurement of Thermal Conductivity and Saturation of Gas Hydrates in Sediment by Thermal Pulse Probe-Time Domain Reflection Technique

open access: yesYankuang ceshi, 2013
So far, gas hydrates not only have been explored in marine and frozen areas of China, but also have been sampled successfully. The thermal conductivity of sediments with gas hydrates is a key parameter for estimating the resource and designing a proper ...
CHEN Qiang   +4 more
doaj  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Generalized saturation game

open access: yesDiscrete Applied Mathematics
We study the following game version of the generalized graph Turán problem. For two fixed graphs F and H, two players, Max and Mini, alternately claim unclaimed edges of the complete graph Kn such that the graph G of the claimed edges must remain F-free throughout the game. The game ends when no further edges can be claimed, i.e.
Balázs Patkós   +3 more
openaire   +2 more sources

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