Results 131 to 140 of about 1,587,603 (313)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
The Ageing, Longevity and Crowding Out Effects on Private and Public Savings: Evidence from Dynamic Panel Analysis [PDF]
Life-cycle theory predicts ageing exerting long-term macroeconomic impacts through the reduction of private savings. Ageing can be brought either through a fall in fertility rates or a rise in longevity. However, empirical research studying macroeconomic
Benjamin ShiJie Wong, Kam-Ki Tang
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Are Retirement Savings Too Exposed to Market Risk? [PDF]
The stock market, as measured by the broad-based Wilshire 5000, declined by 42 percent between its peak in October 9, 2007 and October 9, 2008. Over that one-year period, the value of equities in pension plans and household portfolios fell by $7.4 ...
Alicia H. Munnell, Dan Muldoon
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Savings Behaviour in the Indian Economy [PDF]
An attempt has been made in the present exercise to examine the savings behaviour in the Indian Economy in terms of shift in the growth rates of domestic savings, and in magnitude of income elasticity of the domestic savings at the aggregate and ...
Reddy, N.L., Upender, M.
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Children's Savings Accounts: Why Design Matters [PDF]
, 2008 Estimates how specific features of CSAs -- supplemental grants, federal matches, private contributions, and nontaxability -- would affect the impact of CSAs on wealth distribution.
Adam Carasso +3 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Growth in institutional savings [PDF]
Saving and investment ; Capital market ; Capital ...
anonymous
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source