Results 41 to 50 of about 493,357 (262)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Multi-Attribute Decision-Making Methods as a Part of Mathematical Optimization

open access: yesMathematics, 2019
Optimization problems are relevant to various areas of human activity. In different cases, the problems are solved by applying appropriate optimization methods. A range of optimization problems has resulted in a number of different methods and algorithms
Irina Vinogradova
doaj   +1 more source

Sistem Pendukung Keputusan Untuk Penerimaan Beasiswa Dengan Metode Simple Additive Weighting (SAW) Pada Smkn 1 Ciomas Kabupaten Bogor

open access: yesJurnal Teknologi Informatika & Komputer, 2020
Abstrak: Sebagai lembaga pendidikan formal, SMKN 1 Ciomas merupakan salah satu sekolah yang memberikan beasiswa kepada para siswa. Beasiswa ini ditujukan untuk siswa kurang mampu.
Yahdi Kusnadi   +1 more
doaj   +1 more source

Analysis of the SAW Model in the Selection of Majors at ISB Atma Luhur

open access: yesJurnal Sisfokom, 2023
The department is part of the faculty, and is the focus of the field of study chosen by students. The choice of majors is very important to think about beforehand because it will have an impact on the results of these graduates and the job prospects ...
Fitriyani Fitriyani   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

PENERAPAN MADM DENGAN METODE SAW UNTUK MENENTUKAN TARGET PROMOSI BERDASARKAN ASAL JURUSAN DI SEKOLAH

open access: yesSimetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer, 2021
Penerimaan Mahasiswa Baru (PMB) adalah proses yang sangat penting untuk merekrut mahasiswa baru, di mana jumlah mahasiswa sangat penting untuk operasional dan perencanaan pengembangan Perguruan Tinggi Swasta (PTS).
B. T. SUTRISNO, Widyastuti Andriyani
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Sistem Pemilihan Bakal Calon Legislatif oleh Partai Politik dengan Metode Simple Additive Weighting

open access: yesEdumatic
The Regional Leadership Council of the Grinding Party experienced difficulties during the general election in 2019 where legislative candidates could not meet the party's target of 2 seats.
Ella Alpionita   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

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