Results 41 to 50 of about 136,761 (272)

Suzaku Confirms NGC~3660 is an Unabsorbed Seyfert 2 [PDF]

, 2016
An enigmatic group of objects, unabsorbed Seyfert 2s may have intrinsically weak broad line regions, obscuration in the line of sight to the BLR but not to the X-ray corona, or so much obscuration that the X-ray continuum is completely suppressed and the
Bianchi, S., Brightman, M., Matt, G., Nandra, K., Rivers, E., Ueda, Y.   +5 more
core   +2 more sources

Knowledge mobilisation for policy development: implementing systems approaches through participatory dynamic simulation modelling

Health Research Policy and Systems, 2017
Background Evidence-based decision-making is an important foundation for health policy and service planning decisions, yet there remain challenges in ensuring that the many forms of available evidence are considered when decisions are being made ...
Louise Freebairn, Lucie Rychetnik, Jo-An Atkinson, Paul Kelly, Geoff McDonnell, Nick Roberts, Christine Whittall, Sally Redman   +7 more
doaj   +1 more source

The aperiodic timing behaviour of the accretion-driven millisecond pulsar SAX J1808.4-3658

, 2003
We studied the aperiodic X-ray timing behaviour of the accreting millisecond pulsar SAX J1808.4-3658. The source was recently found to be the first accreting millisecond pulsar that shows the kilohertz quasi-periodic oscillations (kilohertz QPOs) that ...
van der Klis, M., van Straaten, S., Wijnands, R.   +2 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The EXpert PANel Decision (EXPAND) method: a way to measure the impact of diverse quality improvement activities of clinical networks

Public Health Research & Practice, 2018
Objectives and importance of study: Evaluating impacts of quality improvement activities across diverse clinical focus areas is challenging. However, evaluation is necessary to determine if the activities had an impact on quality of care and resulted in ...
Amanda Dominello, Elizabeth M Yano, Emily Klineberg, Sally Redman, Jonathan C Craig, Bernadette Brown, Deanna Kalucy, Mary Haines   +7 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Decision makers’ experience of participatory dynamic simulation modelling: methods for public health policy

BMC Medical Informatics and Decision Making, 2018
Background Systems science methods such as dynamic simulation modelling are well suited to address questions about public health policy as they consider the complexity, context and dynamic nature of system-wide behaviours. Advances in technology have led
Louise Freebairn, Jo-An Atkinson, Paul M. Kelly, Geoff McDonnell, Lucie Rychetnik   +4 more
doaj   +1 more source

Discovery of an eccentric 30 days period in the supergiant X-ray binary SAX J1818.6-1703 with INTEGRAL

, 2008
SAX J1818.6-1703 is a flaring transient X-ray source serendipitously discovered by BeppoSAX in 1998 during an observation of the Galactic centre. The source was identified as a High-Mass X-ray Binary with an OB SuperGiant companion.
Bodaghee, Bodaghee, Bozzo, Chaty, Crowther, Dean, Filliatre, Grebenev, Grebenev, Götz, Horne, in 't Zand, in't Zand, in't Zand, J. A. Zurita Heras, Kuulkers, Lebrun, Leyder, Lutovinov, Martins, Negueruela, Negueruela, Oskinova, Pellizza, Press, Revnivtsev, Rodriguez, Runacres, S. Chaty, Sguera, Smith, Ubertini, Vink, Walter, Walter, Winkler, Zurita Heras   +36 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source