Results 201 to 210 of about 298,148 (243)

Chiari II brain malformation is secondary to open spina bifida. [PDF]

Dis Model Mech
Clark M, Edwards TJ, Savery D, Galea GL, Samy N, Pauws E, Kessaris N, Greene NDE, Copp AJ.   +8 more
europepmc   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Superconductivity in kagome metals due to soft loop-current fluctuations. [PDF]

Nat Commun
Schultz DJ, Palle G, Mitra A, Kim YB, Fernandes RM, Schmalian J.   +5 more
europepmc   +1 more source

Donanemab treatment effect by baseline tau burden and disease severity: Observations from the TRAILBLAZER-ALZ 2 trial. [PDF]

Alzheimers Dement
Raket LL, Lu M, Evans CD, Zimmer JA, Sparks J, Collins EC, Shcherbinin S, Wang H, Nery ESM, Epelbaum S, Dell'Agnello G, Brooks DA, Sims JR, Mintun MA.   +13 more
europepmc   +1 more source

Associations between sedentary behavior and allostatic load: The 1970 British Cohort Study. [PDF]

Psychoneuroendocrinology
Chauntry AJ, Diana JC, Li Q, Seeman T, Courtney JB, Tyne WP, Whittaker AC, Turner AI, Teychenne M, Lassalle PP, Zieff G, Gibbs BB, Diaz KM, Puterman E, Lin FC, Kowalsky RJ, Stoner L, Hanson ED, Meyer ML.   +18 more
europepmc   +1 more source

Artificial Intelligence Versus Conventional Scoring for Assessing Small Bowel Capsule Endoscopy Cleanliness in Crohn's Disease. [PDF]

United European Gastroenterol J
Rouveyre R, Le Berre C, Leenhardt R, Collins M, De Massin A, Flamant M, Trang-Poisson C, Bouguen G, Dib N, Histace A, Soude T, Dray X, Bourreille A.   +12 more
europepmc   +1 more source

Validity of the two different scoring methods of the Clinical Dementia Rating scale in staging and detection of cognitive impairment in the Peruvian population. [PDF]

Alzheimers Dement
Senador J, Montesinos R, Custodio B, Huilca J, Agüero K, Verastegui G, Bartolo P, Nuñez-Huanca M, Pereira MFA, Custodio N.   +9 more
europepmc   +1 more source