Results 31 to 40 of about 298,534 (243)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Study of the process $$e^+e^- \rightarrow \eta \pi ^0\gamma $$ e + e - → η π 0 γ in the energy range $$\sqrt{s} = {1.05-2.00}$$ s = 1.05 - 2.00 GeV with the SND detector

European Physical Journal C: Particles and Fields, 2020
The process $$e^+e^-\rightarrow \eta \pi ^0\gamma $$ e + e - → η π 0 γ is studied in the center-of-mass energy range 1.05–2.00 GeV using data with an integrated luminosity of 94.5 $$\hbox {pb}^{-1}$$ pb - 1 collected by the SND detector at the VEPP-2000 $
M. N. Achasov, A. Yu. Barnyakov, A. A. Baykov, K. I. Beloborodov, A. V. Berdyugin, D. E. Berkaev, A. G. Bogdanchikov, A. A. Botov, T. V. Dimova, V. P. Druzhinin, V. B. Golubev, A. N. Kirpotin, L. V. Kardapoltsev, A. S. Kasaev, A. G. Kharlamov, I. A. Koop, A. A. Korol, D. P. Kovrizhin, A. S. Kupich, K. A. Martin, N. A. Melnikova, N. Yu. Muchnoy, A. E. Obrazovsky, E. V. Pakhtusova, K. V. Pugachev, D. V. Rabusov, Yu. A. Rogovsky, Y. S. Savchenko, A. I. Senchenko, S. I. Serednyakov, D. N. Shatilov, Yu. M. Shatunov, D. A. Shtol, D. B. Shwartz, Z. K. Silagadze, I. K. Surin, M. V. Timoshenko, Yu. V. Usov, V. N. Zhabin, V. V. Zhulanov   +39 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

AN 80-YEAR-OLD WOMAN WITH LEFT SHOULDER PAIN [PDF]

Malaysian Family Physician, 2010
This case history illustrates the real life experience and dilemma of an 80-year-old woman in pursuit of medical care for her left shoulder pain. Points for discussion range from clinical features of Pancoast tumor, importance of pain management, good ...
KHOO SB
doaj  

Study of the process $$e^+e^- \rightarrow \eta \eta \gamma $$ e + e - → η η γ in the energy range $$\sqrt{s} = \text{1.17--2.00 }$$ s = 1.17--2.00  GeV with the SND detector

European Physical Journal C: Particles and Fields, 2022
The process $$e^+e^-\rightarrow \eta \eta \gamma $$ e + e - → η η γ is studied in the center-of-mass energy range 1.17–2.00 GeV using data with an integrated luminosity of 201 pb $$^{-1}$$ - 1 collected by the SND detector at the VEPP-2000 $$e^+e^-$$ e +
M. N. Achasov, A. Yu. Barnyakov, K. I. Beloborodov, A. V. Berdyugin, D. E. Berkaev, A. G. Bogdanchikov, A. A. Botov, T. V. Dimova, V. P. Druzhinin, A. N. Kirpotin, L. V. Kardapoltsev, A. S. Kasaev, A. G. Kharlamov, I. A. Koop, A. A. Korol, D. P. Kovrizhin, A. S. Kupich, K. A. Martin, N. A. Melnikova, N. Yu. Muchnoy, A. E. Obrazovsky, E. V. Pakhtusova, K. V. Pugachev, D. V. Rabusov, Yu. A. Rogovsky, A. I. Senchenko, S. I. Serednyakov, D. N. Shatilov, Yu. M. Shatunov, D. A. Shtol, D. B. Shwartz, Z. K. Silagadze, I. K. Surin, M. V. Timoshenko, Yu. V. Usov, V. N. Zhabin, V. V. Zhulanov, SND Collaboration   +37 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Creation of the spacecraft’s command-and-measurement system’s heterogeneous simulation model

Космические аппараты и технологии, 2020
This article presents software tools designed for construction of heterogeneous models by software integration of logical models having their work methods set in the knowledge bases and engineering models created in a technical simulation environment. In
O. S. Isaeva, L. F. Nozhenkova, A. V. Mishurov, A. N. Kamyshnikov, V. V. Evstratko, A. S. Chernigovskiy   +5 more
doaj   +1 more source