Results 71 to 80 of about 1,726,403 (273)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Evaluation of the association between subconjunctival orbital fat prolapse and thyroid-associated orbitopathy

Clinical Interventions in Aging, 2017
Sang Beom HanDepartment of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, KoreaI read with interest the article entitled “Subconjunctival orbital fat prolapse and thyroid ...
Han SB
doaj  

ACADEMIC MOBBING: HIDDEN HEALTH HAZARD AT WORKPLACE [PDF]

Malaysian Family Physician, 2010
Academic mobbing is a non-violent, sophisticated, ‘ganging up’ behaviour adopted by academicians to “wear and tear” a colleague down emotionally through unjustified accusation, humiliation, general harassment and emotional abuse.
KHOO SB
doaj  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Childhood neuroblastoma masquerading as pheochromocytoma: case report

International Medical Case Reports Journal, 2016
Suk-Bae MoonDepartment of Surgery, Kangwon National University Hospital, Kangwon National School of Medicine, Kangwon National University, Chuncheon, South KoreaAbstract: Neuroblastoma is the most common extracranial solid tumor in children.
Moon SB
doaj  

Has gene expression neofunctionalization in the fire ant antennae contributed to queen discrimination behavior?

Ecology and Evolution, 2019
Queen discrimination behavior in the fire ant Solenopsis invicta maintains its two types of societies: colonies with one (monogyne) or many (polygyne) queens, yet the underlying genetic mechanism is poorly understood.
Viet‐Dai Dang, Amir B. Cohanim, Silvia Fontana, Eyal Privman, John Wang   +4 more
doaj   +1 more source

On the Origins of Starburst and Post-Starburst Galaxies in Nearby Clusters

, 1998
HST WFPC2 images in B (F450W) and I (F814W) have been obtained for three starburst (SB) and two post-starburst (PSB) galaxies in the Coma cluster, and for three such galaxies in the cluster DC2048-52.
Barger A. J., Belloni P., Biviano A., Bower R. G., Bower R. G., Briel U. G., Couch W. J., Dressler A., Haynes M. P., James A. Rose, Kauffmann G., Kristi Dendy, Lobo C., MacLaren I., Moss C., Nelson Caldwell, Pickles A. J., Richardson W. H., Soucail G., Watt M. P., White S. D. M.   +20 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source