Results 41 to 50 of about 5,961 (172)

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

open access: yesAdvanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao   +5 more
wiley   +1 more source

Osmosis effect on protein sustained release of Agarose hydrogel for anti-friction performance

open access: yes, 2019
Agarose hydrogel as an efficient carrier for protein model has been considered to optimize the lubrication of artificial hip joints. Elevating the effectiveness of lubricant to reduce frictional coefficient and wear debris to prolong life time of ...
Mahmoodi, Pooya   +3 more
core   +1 more source

Universally Accurate or Specifically Inadequate? Stress‐Testing General Purpose Machine Learning Interatomic Potentials

open access: yesAdvanced Intelligent Discovery, EarlyView.
We investigate MACE‐MP‐0 and M3GNet, two general‐purpose machine learning potentials, in materials discovery and find that both generally yield reliable predictions. At the same time, both potentials show a bias towards overstabilizing high energy metastable states. We deduce a metric to quantify when these potentials are safe to use.
Konstantin S. Jakob   +2 more
wiley   +1 more source

Corrosion resistance investigation of surface modified biocompatible β-titanium alloys

open access: yes, 2021
International audienceIn this work we focused on the corrosion resistance properties of Ti-12Mo-6Zr-2Fe alloy for biomedical applications. Different surface modifications were processed on the TMZF alloy surface and the impact on the corrosion behaviour ...
Claros, C.A. Escobar   +5 more
core   +1 more source

Injectable Bone Cements: A Generational Framework for Bioactivity, Porosity, and Mechanobiological Design at the Nanoscale

open access: yesAdvanced NanoBiomed Research, EarlyView.
Key demographic, biological, and material considerations that drive the need for advanced injectable bone cement technologies. Injectable bone cements (IBCs) are widely used in orthopaedic and craniofacial applications due to their minimally invasive delivery and ability to provide early mechanical stabilisation.
Frank Fei   +2 more
wiley   +1 more source

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

open access: yesBiological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon   +5 more
wiley   +1 more source

Structural Characterisation of Bioactive Glasses [PDF]

open access: yes, 2007
Melt-quenched glasses containing SiO2, CaO, Na2O and P2O5, and sol-gel derived glasses containing SiO2 and CaO are known to have bioactive properties. Foaming of binary sol-gel derived bioactive glasses containing SiO2 and CaO can be used to produce ...
Fitzgerald, Victoria
core  

Application of dynamic modelling and model‐based predictive control to enhance a cooling tower

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Model predictive control (MPC) applied to improve the operation of cooling towers. Abstract Model predictive control (MPC) differs from traditional feedback control by making predictions within a time horizon, providing better control actions for the process.
Douglas de Almeida Giardini   +4 more
wiley   +1 more source

Life Cycle Analysis as a Sustainable Governance Lever for Environmental Performance: Evidence From French SBF 120 Companies

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study draws on neo‐institutional theory, stakeholder theory, and the resource‐based view to examine the relationship between the use of Life Cycle Analysis (LCA) and firms' Environmental Performance (EP). Focusing on French companies listed on the SBF 120 index from 2002 to 2021, it investigates how LCA adoption influences EP across three
Nesrine Ben Ismail, Sami Ben Larbi
wiley   +1 more source

Bridging Stability and Reactivity: Novel Dinucleating Ligand With Rigid Backbone Stabilizes a Cu2O2 Side‐On Peroxido Structure

open access: yesEuropean Journal of Inorganic Chemistry, EarlyView.
The herein‐developed tyrosinase model complex enables the transfer of tyrosinase‐like catalytic oxygenation activity into artificial systems. Therefore, it enables the use of molecular oxygen for oxygenation and oxidation of phenolic substrates at room temperature.
Rosalie Dalhoff   +3 more
wiley   +1 more source

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