Results 191 to 200 of about 53,028 (278)

Non‐Rigid 3D Shape Correspondences: From Foundations to Open Challenges and Opportunities

open access: yesComputer Graphics Forum, EarlyView.
Abstract Estimating correspondences between deformed shape instances is a long‐standing problem in computer graphics; numerous applications, from texture transfer to statistical modelling, rely on recovering an accurate correspondence map. Many methods have thus been proposed to tackle this challenging problem from varying perspectives, depending on ...
A. Zhuravlev   +14 more
wiley   +1 more source

From language matters to stigma‐free communication in diabetes: Evolution, challenges, and next steps

open access: yesDiabetic Medicine, EarlyView.
Abstract Language profoundly shapes how diabetes is perceived, experienced and managed, with the potential to perpetuate stigma or promote dignity and respect. This expert review, conducted by an international, multidisciplinary team, traces the evolution of the global diabetes #LanguageMatters movement and synthesises evidence on the effects of ...
Elizabeth Holmes‐Truscott   +15 more
wiley   +1 more source

TF-loop: deciphering the transcription factor regulatory language for CTCF-mediated chromatin loop based on BERT. [PDF]

open access: yesBrief Bioinform
Qi YX   +8 more
europepmc   +1 more source

Understanding how enzymes work: the journey to ensemble–function studies

open access: yesThe FEBS Journal, EarlyView.
For decades, structure–function has dominated biochemistry. Structures are highly valuable, yet more is needed to achieve a quantitative understanding of biomolecular function, because function emerges from an ensemble of states, rather than a static structure. We describe an ensemble–function framework applied to quantitatively dissect serine protease
Daniel Herschlag, Siyuan Du
wiley   +1 more source

Genetic dissection reveals distinct contributions of the eS31 N‐terminal domain to translational accuracy in Saccharomyces cerevisiae

open access: yesThe FEBS Journal, EarlyView.
The eukaryote‐specific N‐terminal domain (NTD) of eS31 uses two distinct strategies to maintain translation fidelity. During elongation, a positively charged “hotspot” fine‐tunes the selection of incoming aa‐tRNA. During termination, the entire NTD acts as a structural scaffold to ensure the correct positioning of the release factor eRF1.
Qingxuan Gao   +3 more
wiley   +1 more source

What does my network learn? Assessing interpretability of deep learning for EEG. [PDF]

open access: yesImaging Neurosci (Camb)
Göktepe-Kavis P   +3 more
europepmc   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

open access: yesThe FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

open access: yesImmunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu   +24 more
wiley   +1 more source

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