Results 191 to 200 of about 613,611 (237)

Virtual cell construction for artificial intelligence‐driven drug discovery

open access: yesBritish Journal of Pharmacology, EarlyView.
Cells are the fundamental units through which genetic variation and pharmacological perturbations influence disease processes and therapeutic responses. However, cellular responses to intervention are strongly shaped by biological context, creating a central challenge for drug discovery: predicting how specific perturbations reshape cellular systems ...
Yuran Jia   +5 more
wiley   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu   +20 more
wiley   +1 more source

Mapping the Tissue Architecture and Endothelial‐PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics

open access: yesCancer Science, EarlyView.
Spatial multi‐omics mapping of hepatic angiomyolipoma reveals that PEComas tightly co‐localize with endothelial cells, which drive autophagic flux in adjacent tumor cells via a paracrine PDGFD–PDGFRB–Ras axis, establishing a compensatory survival network that operates in parallel to canonical TSC–mTOR defects.
Xinyang Liu   +9 more
wiley   +1 more source

Structural-functional network decoupling in early stage amyotrophic lateral sclerosis reveals cell-type specific transcriptional signatures. [PDF]

open access: yesBMC Med
Luan J   +17 more
europepmc   +1 more source

Adaptive Sampling for BRDF Acquisition

open access: yesComputer Graphics Forum, EarlyView.
We propose a data‐driven adaptive sampling strategy that predicts the optimal sampling pattern and count for BRDF acquisition from a single image, reducing capture time while preserving quality. Abstract The bidirectional reflectance distribution function (BRDF) describes the ratio of incoming radiance to outgoing radiance for all possible pairs of ...
Behnaz Kavoosighafi   +3 more
wiley   +1 more source

Shared and Unique Connectivity Signatures of Reading and Language Deficits. [PDF]

open access: yesJ Cogn Neurosci
Daucourt MC   +5 more
europepmc   +1 more source

Story2Board: A Training‐Free Approach for Expressive Visual Storytelling

open access: yesComputer Graphics Forum, EarlyView.
Abstract We present Story2Board, a training‐free framework for expressive storyboard generation from natural language. Existing methods narrowly focus on subject identity, overlooking key aspects of visual storytelling such as spatial composition, background evolution, and narrative pacing.
D. Dinkevich   +4 more
wiley   +1 more source

PBR‐Inspired Controllable Diffusion for Image Generation

open access: yesComputer Graphics Forum, EarlyView.
Abstract Despite recent advances in text‐to‐image generation, controlling geometric layout and PBR material properties in synthesized scenes remains challenging. We present a pipeline that first produces a G‐buffer (albedo, normals, depth, roughness, shading, and metallic) from a text prompt and then renders a final image through a PBR‐inspired branch ...
Bowen Xue   +3 more
wiley   +1 more source

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