Results 161 to 170 of about 282,346 (273)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen   +2 more
wiley   +1 more source

The Interplay Between Child and Parental Emotional Symptoms: Insights From Super Skills for Life Programme

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT Research has extensively examined the influence of parental well‐being on children's emotional health, yet fewer studies have explored the reciprocal impact of children's emotional health on parents. This study aimed to identify factors associated with parental emotional symptoms and assess the effectiveness of the Super Skills for Life (SSL ...
Teresa Galán‐Luque, Mireia Orgilés
wiley   +1 more source

Cone beam computed tomographic myelography in horses with cervical vertebral compressive myelopathy

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background While computed tomographic (CT) myelography is increasingly available and has been evaluated in alive horses, objective criteria for diagnosing cervical vertebral compressive myelopathy (CVCM) are lacking. Objectives To establish morphometric dimensions of the cervical vertebral canal and spinal cords from horses with CVCM and ...
Sonia González‐Medina   +4 more
wiley   +1 more source

What predicts improvements from home visits: Implementation fidelity or family enjoyment?

open access: yesFamily Relations, EarlyView.
Abstract Objective This study examined how implementation fidelity to Recipe 4 Success, a preventive intervention embedded within home visits, was related to family enjoyment of those home visits and how both implementation fidelity and enjoyment were related to improvements in parents' sensitive scaffolding and toddlers' self‐regulation.
Sarah M. Braaten   +6 more
wiley   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

open access: yesThe FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak   +10 more
wiley   +1 more source

Compound‐Specific Stable Isotope Analysis Reveals Population‐Specific Differences in Chinook Salmon Trophic Level and Basal Resource Use in the Northeast Pacific

open access: yesFisheries Oceanography, EarlyView.
ABSTRACT Chinook salmon exhibit far‐flung and disparate population‐specific marine migrations that have made it difficult to assess their trophic ecology. In this study, we collected returning and resident subadult Fraser River Chinook salmon in 2018 and 2019 from population groups with different known run‐timings (spring, summer, and fall) and marine ...
Jacob E. Lerner, Brian P. V. Hunt
wiley   +1 more source

Magnetic resonance imaging-based classification of trigeminal nerve-superior cerebellar artery relationships. [PDF]

open access: yesWorld J Radiol
Triantafyllou G   +5 more
europepmc   +1 more source

(No) Pets on University Campuses: ‘Animaling’ Citizenship for Pet‐Friendly Spaces

open access: yesThe Geographical Journal, EarlyView.
Short Abstract Rising support for pet‐friendly university campuses is driven largely by assumed human well‐being benefits, even though staff and, to a lesser extent, students, raise concerns about how companion animals can be active participants in campus life.
Clare Holdsworth   +3 more
wiley   +1 more source

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