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The Scaffold Tree: An Efficient Navigation in the Scaffold Universe
2010The Scaffold Tree algorithm (J Chem Inf Model 47:47-58, 2007) allows to organize large molecular data sets by arranging sets of molecules into a unique tree hierarchy based on their scaffolds, with scaffolds forming leaf nodes of such tree. The hierarchy is created by iterative removal of rings from more complex scaffolds using chemically meaningful ...
Steffen Renner +2 more
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Journal of Cell Science, 2001
An emerging theme of mitogen-activated protein kinase (MAPK) cascades is that they form molecular assemblies within cells; the spatial organization of which is provided by scaffold proteins. Yeast Ste5p was the first MAPK cascade scaffold to be described.
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An emerging theme of mitogen-activated protein kinase (MAPK) cascades is that they form molecular assemblies within cells; the spatial organization of which is provided by scaffold proteins. Yeast Ste5p was the first MAPK cascade scaffold to be described.
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Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances.
Journal of Medicinal Chemistry, 2017The use of privileged structures in drug discovery has proven to be an effective strategy, allowing the generation of innovative hits/leads and successful optimization processes.
J. Reis +3 more
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Distributed Scaffolding: Scaffolding Students in Classroom Environments
Educational Psychology Review, 2021This paper traces the origins of the scaffolding construct, placing it in its theoretical-historical context. The paper discusses the connection between Vygotsky’s Zone of Proximal Development (ZPD), and the notion of scaffolding, and explicates the differences between scaffolding and scaffolds.
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Recent Advances in Scaffold Hopping.
Journal of Medicinal Chemistry, 2017Scaffold hopping refers to the computer-aided search for active compounds containing different core structures, which is a topic of high interest in medicinal chemistry.
Ye Hu, Dagmar Stumpfe, J. Bajorath
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Microfabrication of PDLLA scaffolds
Journal of Tissue Engineering and Regenerative Medicine, 2010This study aimed to comprehend the potentialities of the microfabrication to produce tissue-engineering scaffolds. Structures presenting homogeneously distributed pores of size 100 and 200 µm were fabricated through layer-by-layer deposition of filaments of poly(D,L-lactic acid) (PDLLA) prepared from dichloromethane/dimethylformamide solutions ...
Carletti, Eleonora +6 more
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Scaffolding the Self in Onlife
2019Martin Heidegger and Gaston Bachelard, phenomenological philosophers of dwelling and the notion of self, claimed that essentially, we have to dwell in order to be able to think. Building the dwelling is synonymous of being in Heidegger’s perspective, which means that constructing a shelter for our vulnerable bodies is a prerogative for fulfilling our ...
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Proceedings of the 19th ACM Conference on Computer-Supported Cooperative Work & Social Computing, 2016
The development of strong social and emotional skills is central to personal wellbeing. Increasingly, these skills are being taught in schools through well researched curricula. Such social-emotional learning (SEL) curricula are most effective if reinforced by parents, thus transferring the skills into everyday contexts.
Petr Slovák +7 more
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The development of strong social and emotional skills is central to personal wellbeing. Increasingly, these skills are being taught in schools through well researched curricula. Such social-emotional learning (SEL) curricula are most effective if reinforced by parents, thus transferring the skills into everyday contexts.
Petr Slovák +7 more
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Bioresorbable Scaffolds and Bifurcations
Cardiovascular Revascularization Medicine, 2019Item does not contain ...
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Journal of Learning Disabilities, 1998
To situate the concept of scaffolding within a broader context than that addressed by Stone, I discuss it with respect to (a) the historical context of learning disabilities, (b) the emerging focus on learners activity, (c) the reification of learning disabilities, and (d) the unintended effects that frequently occur as a by-product of injudicious ...
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To situate the concept of scaffolding within a broader context than that addressed by Stone, I discuss it with respect to (a) the historical context of learning disabilities, (b) the emerging focus on learners activity, (c) the reification of learning disabilities, and (d) the unintended effects that frequently occur as a by-product of injudicious ...
openaire +2 more sources