Results 201 to 210 of about 122,769 (269)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

First draft genome and genomic analysis of <i>Neofusicoccum parvum</i> isolated from mango (<i>Mangifera indica</i> L.) in Paraguay. [PDF]

Front Fungal Biol
Méndez M, Acuña AM, Morel Escobar M, González MI, Arrúa Alvarenga A, Benítez Rodas G, Da Silva F, Quintana SA.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Differences in Src phosphorylation of PSD-93 and PSD-95 drive differences in scaffolding activity. [PDF]

Protein Sci
Mindlin FA, Sasazawa M, Byrnes J, Bowen ME.   +3 more
europepmc   +1 more source

Regulatory roles of the circRNA-RBP axis in exercise-induced skeletal muscle remodeling: mechanistic controversies and translational illusions. [PDF]

Front Genet
Liu J, Yang Y, Chen H, Liu M, Mao Z, Zheng M.   +5 more
europepmc   +1 more source

Human analogical guidance amplifies LLM performance through cross-domain knowledge activation. [PDF]

Nat Commun
Larraz R, Corma A.
europepmc   +1 more source

Predicting unsafe behaviour from the objective assessment of fatigue manifestation among scaffolders: Evidence from a Quasi-experimental simulation study. [PDF]

PLoS One
Heng PP, Yusoff HM, Hj Illias MR, Fai YJ, Yusoff MFM, Amsah NB, Hod R.   +6 more
europepmc   +1 more source

Effect of Intravascular Lithotripsy on Mitral Annular Calcification: A Cadaveric Study. [PDF]

J Soc Cardiovasc Angiogr Interv
Khan JM, Shin D, Wolff E, West NEJ, Stephens P, Parikh R, Gill H, Chung WB, Robinson NB, Petrossian GA, Cohen DJ, Khalique OK, Beatty B, Ali ZA.   +13 more
europepmc   +1 more source

Structural Optimization and Finite Element Analysis of Variable-Stiffness Biodegradable Vascular Stents. [PDF]

J Funct Biomater
Zhang H, Chen S, Du T, Zhang Y, Wu L, Qiao A.   +5 more
europepmc   +1 more source