Results 111 to 120 of about 9,449,404 (314)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Cosmological effect of coherent oscillation of ultralight scalar fields in a multicomponent universe

open access: yesEuropean Physical Journal C: Particles and Fields
The idea that coherent oscillations of a scalar field, oscillating over a time period that is much shorter than the cosmological timescale, can exhibit cold dark matter (CDM) like behavior was previously established.
Priyanka Saha   +2 more
doaj   +1 more source

THE MODEL FOR FINAL STAGE OF GRAVITATIONAL COLLAPSE MASSLESS SCALAR FIELD

open access: yesOdessa Astronomical Publications, 2016
It is known that in General relativity, for some spherically symmetric initial conditions, the massless scalar field (SF) experience the gravitational collapse (Choptuik, 1989), and arise a black hole (BH). According Bekenstein, a BH has no "hair scalar",
V. D. Gladush, D. V. Mironin
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Regular and Chaotic Regimes in Scalar Field Cosmology

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2006
A transient chaos in a closed FRW cosmological model with a scalar field is studied. We describe two different chaotic regimes and show that the type of chaos in this model depends on the scalar field potential.
Alexey V. Toporensky
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

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