Results 71 to 80 of about 2,268,510 (323)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Learning mathematics with personal mobile devices in school: a multigroup invariance analysis of acceptance among students and teachers

Frontiers in Education
Students’ use of personal mobile devices (PMDs), including smartphones, tablets, and laptops, in mathematics classrooms globally has become feasible due to the implementation of the bring your own device (BYOD) initiatives and policies in schools ...
Cloneria Nyambali Jatileni, Sari Havu-Nuutinen, Susanna Pöntinen, Jari Kukkonen   +3 more
doaj   +1 more source

Local Availability of mathematics and number scaling: Effects on quantum physics

, 2012
Local availability of mathematics and number scaling provide an approach to a coherent theory of physics and mathematics. Local availability of mathematics assigns separate mathematical universes, U_{x}, to each space time point, x.
Benioff, Paul
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Psychometric Properties of the Sources of Counseling Self Efficacy in a Sample of Malaysian Secondary School Counselors

SAGE Open, 2020
Self-efficacy has been considered an essential mediator and predictor of individual counseling performance. As there is no existing scale to measure counseling self-efficacy in the counseling domain, the Sources of Middle School Mathematics Self-Efficacy
Ooi Pei-Boon, Wan Marzuki Wan Jaafar, Ang Chin-Siang, Chan Nee-Nee   +3 more
doaj   +1 more source

Wheeler-DeWitt Quantization of Gravity Models of Unified Dark Energy and Dark Matter

, 2017
First, we describe the construction of a new type of gravity-matter models based on the formalism of non-Riemannian space-time volume forms - alternative generally covariant integration measure densities (volume elements) defined in terms of auxiliary ...
Bryce S. DeWitt, N. A. Bahcall, Nima Arkani-Hamed, P. J. E. Peebles   +3 more
core   +1 more source

Production of scalar {ital K{bar K}} molecules in {phi} radiative decays [PDF]

, 1996
The potentialities of the production of the scalar K{bar K} molecules in {phi} radiative decays are considered beyond the narrow resonance width approximation. It is shown that B{bold (}{phi}{r_arrow}{gamma}f{sub 0}(a{sub 0}){r_arrow}{gamma}{pi}{pi}({pi}{
N.N.Achasov, V.V.Gubin, V.I.Shevchenko S.L.Sobolev Institute for Mathematics, Novosibirsk, Institute for Theoretical, E. Physics, Moscow   +6 more
semanticscholar   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Integral and fractional equations, positive solutions, and Schaefer's fixed point theorem [PDF]

Opuscula Mathematica, 2016
This is the continuation of four earlier studies of a scalar fractional differential equation of Riemann-Liouville type \[D^qx(t) = -f(t,x(t)), \quad \lim_{t\to 0^+} t^{1-q} x(t) = x^0 \in\Re \quad (0 \lt q \lt 1), \tag {a}\] in which we first invert it ...
L. C. Becker, T. A. Burton, I. K. Purnaras   +2 more
doaj   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source