Results 81 to 90 of about 7,077 (267)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interacting quintessence in light of generalized uncertainty principle: cosmological perturbations and dynamics

European Physical Journal C: Particles and Fields, 2021
We consider a cosmological scenario endowed with an interaction between the universe’s dark components – dark matter and dark energy. Specifically, we assume the dark matter component to be a pressure-less fluid, while the dark energy component is a ...
Andronikos Paliathanasis, Genly Leon, Wompherdeiki Khyllep, Jibitesh Dutta, Supriya Pan   +4 more
doaj   +1 more source

Spectral Action for Scalar Perturbations of Dirac Operators [PDF]

Letters in Mathematical Physics, 2011
We investigate the leading terms of the spectral action for odd-dimensional Riemannian spin manifolds with the Dirac operator perturbed by a scalar function. We calculate first two Gilkey-de Witt coefficients and make explicit calculations for the case of $n$-spheres with a completely symmetric Dirac.
Sitarz, Andrzej, Zając, Artur
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Missing scalars at the cosmological collider

Journal of High Energy Physics, 2021
Light scalar fields typically develop spatially varying backgrounds during inflation. Very often they do not directly affect the density perturbations, but interact with other fields that do leave nontrivial signals in primordial perturbations.
Qianshu Lu, Matthew Reece, Zhong-Zhi Xianyu   +2 more
doaj   +1 more source

Scalar perturbation and stability of Ricci dark energy

Physics Letters B, 2009
The Ricci dark energy (RDE) proposed to explain the accelerating expansion of the universe requires its parameter $α< 1$, whose value will determine the behavior of RDE. In this Letter, we study the scalar perturbation of RDE with and without matter in the universe, and we find that in both cases, the perturbation is stable if $α> 1/3$, which ...
Feng, Chao-Jun, Li, Xin-Zhou
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Stability of a Noncanonical Scalar Field Model during Cosmological Date

Advances in High Energy Physics, 2016
Using the noncanonical model of scalar field, the cosmological consequences of a pervasive, self-interacting, homogeneous, and rolling scalar field are studied.
Z. Ossoulian, T. Golanbari, H. Sheikhahmadi, Kh. Saaidi   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Inflation without an inflaton

Physical Review Research
We propose a novel scenario in which scalar perturbations, which seed the large-scale structure of the universe, are generated without relying on a scalar field (the inflaton).
Daniele Bertacca, Raul Jimenez, Sabino Matarrese, Angelo Ricciardone   +3 more
doaj   +1 more source