Results 131 to 140 of about 3,208,254 (218)

Multi-scale model of axonal and dendritic polarization by transcranial direct current stimulation in realistic head geometry. [PDF]

Brain Stimul, 2023
Aberra AS, Wang R, Grill WM, Peterchev AV.   +3 more
europepmc   +1 more source

Large scale model of the human brain

BMC Neuroscience, 2009
Izhikevich Eugene M
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

MAFNet: A novel adaptive multi-scale model for fine-grained grading of diabetic retinopathy. [PDF]

Sci Rep
Sun L, Peng Q, Xiao X, Liu J, Li Y, Shu D, Xue J.   +6 more
europepmc   +1 more source

Dynamics of streamflow permanence in a headwater network: Insights from catchment-scale model simulations. [PDF]

J Hydrol (Amst), 2023
Mahoney DT, Christensen JR, Golden HE, Lane CR, Evenson GR, White E, Fritz K, D'Amico E, Barton C, Williamson T, Sena K, Agouridis C.   +11 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Modeling intraindividual means and variances from ecological momentary assessment data: comparing standard computational formulas to mixed-effects location-scale model estimates. [PDF]

J Behav Med
Wang WL, Yang CH, Nordgren R, Li J, Intille S, Dunton GF, Hedeker D.   +6 more
europepmc   +1 more source

Genome-scale model of Pseudomonas aeruginosa metabolism unveils virulence and drug potentiation. [PDF]

Commun Biol, 2023
Dahal S, Renz A, Dräger A, Yang L.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Evaluation of Genome-Scale Model Reconstruction Strategies for <i>Lentilactobacillus kefiri</i> DH5 and Deciphering Its Metabolic Network. [PDF]

Metabolites
Esembaeva MA, Kulyashov MA, Sokolova TS, Akberdin IR, Sazonov AE.   +4 more
europepmc   +1 more source