Results 81 to 90 of about 1,001,350 (314)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Land Quality, Development and Space: Does Scale Matter?
European Spatial Research and Policy, 2013 This study analyzes empirically the relationship between land quality decline and the spatial distribution of per capita income observed in Italy at different spatial scales and geographical divisions.
Luca Salvati
doaj +1 more source
Journal of Advances in Modeling Earth Systems, 2021 Stochastic representation of the influence of the subgrid‐scales on the resolved scales in weather and climate models has been shown to improve ensemble spread and resolved variability.
Julie Bessac +4 more
doaj +1 more source
Edge detection using topological gradients: a scale-space approach [PDF]
, 2014 International audienceWe provide in this paper a link between two methods of edge detection: edge detection using scale-space analysis, and edge detection using topological asymptotic analysis.
Amstutz, Samuel, Fehrenbach, Jérôme
core +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Shape recognition using orientational and morphological scale‐spaces of curvatures
IET Computer Vision, 2015 In this study, a scale‐invariant representation for closed planar curves (silhouettes) is proposed. The orientations of all points within the Gaussian scale‐space of the curve are extracted.
Erdem Akagündüz
doaj +1 more source
Visualising higher-dimensional space-time and space-scale objects as projections to ℝ3 [PDF]
PeerJ Computer Science, 2017 Objects of more than three dimensions can be used to model geographic phenomena that occur in space, time and scale. For instance, a single 4D object can be used to represent the changes in a 3D object’s shape across time or all its optimal ...
Ken Arroyo Ohori +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Scale Spaces on Lie Groups [PDF]
, 2007 In the standard scale space approach one obtains a scale space representation u:R of an image by means of an evolution equation on the additive group (R d ,¿+¿). However, it is common to apply a wavelet transform (constructed via a representation of a Lie-group G and admissible wavelet ¿) to an image which provides a detailed overview of the group ...
Duits, R., Burgeth, B.
openaire +2 more sources
Bubbling and Large-Scale Structures in Avalanche Dynamics
, 1999 Using a simple lattice model for granular media, we present a scenario of self-organization that we term self-organized structuring where the steady state has several unusual features: (1) large scale space and/or time inhomogeneities and (2) the ...
Krishnamurthy, Supriya +2 more
core +1 more source