Results 141 to 150 of about 3,310,062 (250)

Optimisation and Scale-Up of the Heterologous Production of the Antifungal Protein PeAfpA From Penicillium expansum in Stirred-Tank Bioreactors. [PDF]

Microb Biotechnol
de Ovalle S, Garrigues S, Gimeno-Alcañiz JV, Mercader JV, Abad-Fuentes A, Marcos JF, Manzanares P.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Systematic Scale-Up of Mechanochemical Paracetamol-Oxalic Acid Cocrystal Synthesis across Multiple Milling Technologies. [PDF]

Org Process Res Dev
Schöbel JH, Gopinath D, Felderhoff M.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Rapid scale-up of hospital-at-home services during wartime: lessons learned from the Sheba Medical Center experience. [PDF]

Front Med (Lausanne)
Ekka Zohar A, Fizdel B, Aroshass L, Vaserman L, Barkai G, Edelman S, Sarafraz R, Leshem E, Peri M, Biber A, Nir YF, Segal G.   +11 more
europepmc   +1 more source

Scaling up diversity to scale up nutrition

, 2019
Schlecht, Martin Thomas, Berndt, Sascha, Greber, Josefine, Marinko, Jan, Archibong, Ukeme Okon, Schmidt, Anja, Speckhahn, Carolin, Weinsheimer, Hanna   +7 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

From batch to continuous electrocoagulation: integrating hydrodynamics and process parameters for efficient fluoride removal and reactor scale-up. [PDF]

Environ Sci Pollut Res Int
Companhia BJF, Scalize PS.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Recent advances in three-dimensional nanoflower-based membrane engineering for water and wastewater treatment: from fundamental mechanisms to scale-up. [PDF]

RSC Adv
Khalili Moradkhanloo S, Kumar Das R, Leung SN, Kaur Brar S.   +3 more
europepmc   +1 more source