Results 191 to 200 of about 3,194,760 (251)

Optimization and scale up strategies for reproducible AAV enrichment step on CIMmultus^® QA HR line. [PDF]

Gene Ther
Žigon R, Drmota Prebil S, Švigelj T, Kozjak K, Žvanut T, Leskovec M, Štrancar A.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Are costs optimized as scale-up of Choose to Move-an effective health-promoting intervention for older adults-proceeds? [PDF]

Int J Behav Nutr Phys Act
Szewczyk Z, Macdonald HM, Pinheiro MB, Nettlefold L, Sims Gould J, McKay HA.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Global disparities in the introduction, scale-up, and effectiveness evaluation of COVID-19 vaccines. [PDF]

Nat Commun
Pesce M, Feikin DR, Higdon MM, O'Brien KL, Patel MK, Rearte A, Vizzotti C, Wilder-Smith A, Parker EPK.   +8 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Scale-up production of [²¹¹At]PSMA-5 using automated synthesizer for Investigator-Initiated clinical trial. [PDF]

EJNMMI Radiopharm Chem
Naka S, Watabe T, Shirakami Y, Ooe K, Kurimoto K, Sakai T, Toyoshima A, Murakami M, Kon Y, Haba H, Cardinale J, Giesel FL, Isohashi K, Tomiyama N.   +13 more
europepmc   +1 more source

CAU-10-H: Synthesis Scale-Up at the Pilot Scale, Techno-Economic Analysis, and Application in a Full-Scale Cooling System. [PDF]

Ind Eng Chem Res
Mertin KS, Mohtar A, Bordonhos M, Pinto ML, May T, Herrmann R, Stock N.   +6 more
europepmc   +1 more source

Adoption, scale-up, and sustainability of a neuropalliative care model: qualitative exploration of pre-implementation barriers and enablers. [PDF]

BMC Health Serv Res
Ang K, Chiu FY, Lim GZ, Chen SJY, Lum E.
europepmc   +1 more source

A fluffy nanofiber scaffold-based microenvironment enables a simplified, biology-centric scale-up strategy for mesenchymal stem/stromal cell culture. [PDF]

Front Bioeng Biotechnol
Iwakami M, Awitan GEG, Yamamoto R, Kino-Oka M.   +3 more
europepmc   +1 more source