Results 101 to 110 of about 10,082,734 (310)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Studies on Droplet Size Distribution of Oil-in-Water Emulsion in SMX Static Mixer

Journal of Applied Fluid Mechanics, 2018
Oil droplet size distribution of an emulsion produced by Sulzer Chemtech's static SMX static mixer under flow condition was experimentally studied and reported. The dispersed phase of vegetable oil-in-water (O/W) emulsion produced through static mixer by
L. Muruganandam, D. Kunal, G. O. Melwyn
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Lateral shifting of gold particles on a metal surface

Discover Applied Sciences
Owing to the intricate interplay between light and matter, the scattering optical force has garnered considerable attention in scientific research. This force invariably propels particles along the trajectory of light propagation.
Yanan Fu, Kongwen Fu, Changjun Min, Yuquan Zhang, Xiaocong Yuan   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Parallel Integral Equation-Based Nonoverlapping DDM for Solving Challenging Electromagnetic Scattering Problems of Two Thousand Wavelengths

International Journal of Antennas and Propagation, 2019
In this paper, a parallel nonoverlapping and nonconformal domain decomposition method (DDM) is proposed for fast and accurate analysis of electrically large objects in the condition of limited resources.
Qin Su, Yingyu Liu, Xunwang Zhao, Zongjing Gu, Chang Zhai, Zhongchao Lin, Weijun Wu   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Fast net-forming of biomimetic hierarchical structures with robust oil/water separation performance

Microsystems & Nanoengineering
Biomimetic hierarchical structures (BHS) are a powerful strategy for engineering functional surfaces with exceptional properties. However, their practical application is limited by inefficient, costly and complex fabrication methods.
Jianan Fu, Liangchi Zhang, Zhen Li, Jiang Ma   +3 more
doaj   +1 more source