Results 51 to 60 of about 10,082,734 (310)

Scaling Laws Do Not Scale

open access: yesProceedings of the AAAI/ACM Conference on AI, Ethics, and Society
Recent work has advocated for training AI models on ever-larger datasets, arguing that as the size of a dataset increases, the performance of a model trained on that dataset will correspondingly increase (referred to as “scaling laws”). In this paper, we draw on literature from the social sciences and machine learning to critically interrogate these ...
Fernando Diaz 0001, Michael Madaio
openaire   +3 more sources

Forecasting at Scale

open access: yesThe American Statistician, 2017
Forecasting is a common data science task that helps organizations with capacity planning, goal setting, and anomaly detection. Despite its importance, there are serious challenges associated with producing reliable and high quality forecasts — especially when there are a variety of time series and analysts with expertise in time series modeling are ...
Taylor, Sean J, Letham, Benjamin
openaire   +2 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Strings at the intermediate scale or is the Fermi scale dual to the Planck scale? [PDF]

open access: yesPhysics Letters B, 1999
We show that if the string scale is identifed with the intermediate scale, $M_s=\sqrt{M_W M_{Planck}} \sim 10^{11}$ GeV, then the notorious hierarchy, $M_W/M_{Planck} \sim 10^{-16}$, can be explained using only $M_c/M_s \sim 0.01 \sim α_{GUT} $ as small input parameters, where $M_c$ is the compactification scale.
Burgess, C. P.   +2 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Report on improving smallholder women farmers’ access to finance for small-scale irrigation technologies

open access: yes, 2023
Widespread use of small power pumps in South Asia has revolutionized agricultural production since the 1970s. In the past few years, solar photovoltaic pumps have become affordable alternatives to diesel and grid-powered electric pumps.
Feed the Future Innovation Lab for Small Scale Irrigation
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

European scale-up report

open access: yes, 2020
Unique view of the landscape and management of European scale-ups The widely held belief that European scale-ups are mainly innovative tech companies is incorrect; they can be found in all sectors and at all levels of innovation.
Collewaert, Veroniek   +2 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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