Results 91 to 100 of about 8,984,201 (303)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Tensioned flexible riser vibrations under wave excitation, an investigation on the scale effect

Frontiers in Marine Science
In order to study the scale effect in wave-structure interactions and the role that structure-related parameters (tension T or bending stiffness EI) plays, riser model tests under regular waves were conducted using the model with multiple geometric ...
Yunli Feng, Sunwei Li, Daoyi Chen, Daoyi Chen   +3 more
doaj   +1 more source

Modification of the Casimir Effect due to a Minimal length scale

, 2005
The existence of a minimal length scale, a fundamental lower limit on spacetime resolution is motivated by various theories of quantum gravity as well as string theory. Classical calculations involving both quantum theory and general relativity yield the
Harbach, Ulrich, Hossenfelder, Sabine
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Numerical simulation of size effect on shear strength and deformation behavior of rockfill materials

Yantu gongcheng xuebao, 2018
The scale effect of rockfill materials is crucial to predicting the strength and deformation of earth-rockfill dams. Due to their large particle size and the experimental restrictions, large triaxial tests on full scale samples are seldom conducted.
SHAO Xiao-quan 1,2, CHI Shi-chun 1,2, TAO Yong 3
doaj   +1 more source

Size scale effect in cavitation erosion [PDF]

An overview and data analyses pertaining to cavitation erosion size scale effects are presented. The exponents n in the power law relationship are found to vary from 1.7 to 4.9 for venturi and rotating disk devices supporting the values reported in the ...
Buckley, D. H., Rao, B. C., Rao, P. V.
core   +1 more source

New mechanism of generation of large-scale magnetic field in a sheared turbulent plasma

, 2007
A review of recent studies on a new mechanism of generation of large-scale magnetic field in a sheared turbulent plasma is presented. This mechanism is associated with the shear-current effect which is related to the W x J-term in the mean electromotive ...
Blackman, Brandenburg, Brandenburg, Brandenburg, Brandenburg, Brandenburg, Field, I. Rogachevskii, Kleeorin, N. Kleeorin, Rogachevskii, Rogachevskii, Rogachevskii, Rogachevskii, Rogachevskii, Rädler, Rüdiger, Sur   +17 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Discussion on some problems observed in high earth-rockfill dams

Yantu gongcheng xuebao, 2018
A few key issues influencing the safety of high earth-rockfill dams are discussed, and the research progress in recent years is reviewed. The factors which influence the scale effects of coarse-grained materials are analyzed.
WANG Xiao-gang
doaj   +1 more source