Results 141 to 150 of about 830,081 (261)

Impact of Fostamatinib on Inflammatory Biomarkers in Hospitalized Patients With COVID-19. [PDF]

Crit Care Explor
Da Cruz RS, Teague HL, Ramos-Benitez MJ, Malavez-Cajigas SJ, Williams T, Miao R, Tian X, Lin G, Busse LW, Khan A, Moskowitz A, Hager DN, Rice TW, Ginde AA, Iovine NM, Chen P, Safdar B, Gibbs KW, Javaheri A, de Wit M, Harkins M, Hudock K, Merck LH, Barksdale A, Sturek JM, Schrager H, Shapiro NI, Lanspa M, Harris E, Sellers S, Goodwin AJ, Tidswell MA, Filbin MR, Shotwell MS, Semler MW, Self WH, Collins SP, Strich JR, Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV-4) Host Tissue Investigators.   +38 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Role of thromboelastography in risk stratifying patients with traumatic brain injury on prehospital antiplatelet agents. [PDF]

Trauma Surg Acute Care Open
Okonya T, Gulati S, Reeson EA, Mailolo JK, Rahaman CA, Warrington NV, Matthees NG, Low TM, Kupanoff KM, Weinberg JA, Bogert JN.   +10 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Top-down medial prefrontal cortex-to-hypothalamic paraventricular nucleus circuit regulates social avoidance and conditioned fear in male mice. [PDF]

Cell Discov
Wang Y, Pan XY, Wu B, Li DY, Wang SW, Qin XY, Shan QH, Chen P, Hu P, Wang H, Liu RY, Gong H, Zhou JN.   +12 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Inhibition of SGK1 Alleviates Apoptosis and Oxidative Stress in Dry Eye Disease by Activating FoxO3a-Mediated Autophagy. [PDF]

Invest Ophthalmol Vis Sci
Tang Y, Chen Z, Jiang J, Zhang D, Chu Y, Li B, Zhang Q, Hu K.   +7 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Trichodiene: a committed intermediate and a chink in the armor of mycotoxigenic <i>Fusarium</i>species. [PDF]

Appl Environ Microbiol
Chalivendra S.
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source