Results 191 to 200 of about 833,494 (262)

Inhibition of circZFX suppresses malignant phenotypes in cholangiocarcinoma via the miR-654-3p/HDGF and YAP1 signaling activation. [PDF]

Biol Direct
Liang T, Gong C, Yang X, Shen J, Jiang G, Liu J, Yang G, Guo L.   +7 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

FAK inhibitor suppresses ovarian cancer growth by inhibiting tumor angiogenesis. [PDF]

Cancer Cell Int
Shen J, Su Z, Shan Y, Wang Y, Meng Y, Li Z, Miao S, Zhang J, Yan X.   +8 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Engineered microtissue systems for identifying the roles of Wnt and YAP signaling in hepatoblast differentiation and organization. [PDF]

Mater Today Bio
Grenci B, Tsai A, Zobus K, Underhill GH.
europepmc   +1 more source

Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal transport that are rescued by p38α inhibition. [PDF]

Nat Neurosci
Moretto E, Masato A, Panzi C, Lopes AT, Stuart S, De La-Rocque S, Caso MG, White IJ, Harris SS, Busche MA, Schiavo G.   +10 more
europepmc   +1 more source

Mechanistic insights into SGLT2 inhibition in Takotsubo syndrome. [PDF]

Eur Heart J Cardiovasc Pharmacother
Trimaille A, Tatarcheh T, Granier A, Schini-Kerth V, Morel O.   +4 more
europepmc   +1 more source

The PDE5 inhibitor vardenafil enhances glutamatergic transmission through amyloid-beta and cellular prion protein. [PDF]

Neurotherapeutics
Kafi MAA, Passalacqua M, Villa V, Thellung S, Corsaro A, Grimaldi R, Spatola E, Florio T, Baldelli P, Ricciarelli R.   +9 more
europepmc   +1 more source

Transcranial magnetic stimulation and motor overflow: a systematic review in neurological disorders. [PDF]

Front Neurosci
Pereira GS, De Araújo JE, Rosa GHM, Zhang K, Da Silva ML, Ferreira LMA.   +5 more
europepmc   +1 more source

R788 is Associated with Neuroprotective Effects in Experimental Ischemic Stroke Models via Modulation of the STAT1/Nrf2/GPX4 Axis. [PDF]

J Inflamm Res
Yang Y, Wang J, Zhou H, Jiang C, Zhu Z, Wang Y.   +5 more
europepmc   +1 more source