Results 191 to 200 of about 830,081 (261)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Creatine metabolism regulates trophectoderm formation in early mouse embryos via an energy-cytoskeleton-YAP axis. [PDF]

J Biol Chem
Chen X, Pan B, Qin J, Wei Y, Du K, Ning A, Sun T, Wang C, Zou S, Su X, Wang M, Guo Y, Xiong X, Pei S, Zang S, Zhang C, Ye J, Yu G, Liang Q, Zhou G.   +19 more
europepmc   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Ursodeoxycholic acid mitigates cerebral ischemia/reperfusion injury by inhibiting thrombin-induced lipid peroxidation through activation of ALDH3A1. [PDF]

Redox Biol
Liu A, Yang T, Li Z, Luo R, Zhu C, Du S, Chen W, Duan J.   +7 more
europepmc   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Enhancing anandamide signalling through fatty acid amide hydrolase inhibition: An update on the pharmacological strategy for treating psychiatric disorders. [PDF]

Transl Psychiatry
Couttas TA, Hoffmann AE, Jieu B, Golla FR, Shepherd CE, Leweke FM, Rohleder C.   +6 more
europepmc   +1 more source

Mobile alcohol-specific inhibition training in adolescents and young adults with alcohol use disorder: study protocol for a randomized controlled feasibility trial. [PDF]

Front Psychol
Schuerch K, Koenig T, Guarriello A, Soravia L, Berger T, Adorjan K, Moggi F, Stein M.   +7 more
europepmc   +1 more source

Universal principles of cell population growth follow from local contact inhibition. [PDF]

iScience
Kimmel GJ, Marzban S, Damaghi M, Traulsen A, Anderson ARA, West J, Altrock PM.   +6 more
europepmc   +1 more source

ZnO Nanocrystals Inhibit <i>Escherichia coli</i> Biofilms by Suppressing <i>glgA</i>- and <i>gltB</i>-Dependent EPS Biosynthesis. [PDF]

Int J Nanomedicine
Tian X, Zhou C, Bai Q, Chen Y, Cai R, Lai J, Ye L, Feng W, Wang Y, Song Q, Liu T.   +10 more
europepmc   +1 more source

Effects of Neural Correlates of Food-Specific Intentional Inhibition in Predicting Body Fat Loss for Overweight and Normal-Weight Young Adults: The Mediation of Restrained Eating. [PDF]

Nutrients
Liu X, Li M, Song S, Cui Y, Chen H.
europepmc   +1 more source