Results 111 to 120 of about 6,334,977 (297)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Scale inhibitor squeeze treatment efficiency in unfractured and fractured wells

, 2010
Deployment of scale inhibitor squeeze treatments generally involves injection of aqueous solutions at pressures higher than the formation pressure and at temperatures lower than the formation temperature.
Sorbie, Ken; id_orcid, Ishkov, Oleg, Oleg Ishkov, Mackay, Eric James; id_orcid, Ken Sorbie, Mackay, Eric; id_orcid, Eric Mackay, Sorbie, Kenneth Stuart; id_orcid   +7 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Scale inhibitor squeeze treatments based on modelling studies

, 2010
Scale inhibitor treatment programs for crude producers in Saudi Aramco have been exceptional in the oil industry. Development and application of various scale inhibitor treatment programs that incorporate the latest university industry-funded research ...
Mackay, Eric J.; id_orcid, Al-Buali, M H, Muhammad H. Al-Buali, Al-Saadoun, Turki F., Raju, K U, Raju, Kris U., Kris U. Raju, Saudi Aramco, Mackay, Eric James; id_orcid, Turki F. Al-Saadoun, Al-Saadoun, T F, Eric J. Mackay, Aramco, Saudi, Al-Buali, Muhammad H.   +13 more
core   +1 more source

Longer Duration of MAO-B Inhibitor Exposure is Associated with Less Clinical Decline in Parkinson’s Disease: An Analysis of NET-PD LS1

Journal of Parkinson’s Disease, 2017
Background: Monoamine oxidase type B (MAO-B) inhibitors exhibit neuroprotective effects in preclinical models of PD but clinical trials have failed to convincingly demonstrate disease modifying benefits in PD patients.
Robert A. Hauser, Ruosha Li, Adriana Pérez, Xuehan Ren, Dan Weintraub, Jordan Elm, John L. Goudreau, John C. Morgan, John Y. Fang, Michael J. Aminoff, Chadwick W. Christine, Rohit Dhall, Chizoba C. Umeh, James T. Boyd, Natividad Stover, Maureen Leehey, Richard M. Zweig, Anthony P. Nicholas, Ivan Bodis-Wollner, Allison Willis, Karl Kieburtz, Barbara C. Tilley,   +22 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Korróziós Inhibitor Koncentráció Meghatározás

Az olajipar a világ egyik legnagyobb és legjelentősebb gazdasági szektora. Az olajokat kitermelésük után különböző termékek előállítására használják, például benzin, dízel, kerozin és kenőolaj.
Szalai, László
core