Results 111 to 120 of about 719,803 (305)
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Inhibition of pitting on carbon steel [PDF]
, 2011 Carbon dioxide and hydrogen sulphide pitting related failures are a prime concern in oil and gas internal pipelines. Often, these types of failure have a great impact on safety and environmental matters and can cause severe financial consequences to the
Ismail, Ismarullizam Mohd
core
Guanidine as A Starting Martial for Preparing a Scale Inhibitor [PDF]
This study presents the synthesis and evaluation of a novel phosphonate-based scale inhibitor using guanidine as the starting material. Given guanidine’s highly reactive nature and multiple substitution sites, it was chemically modified by introducing ...
Dakhil, Othman O. +3 more
core +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Emulsified scale inhibitor systems technical report 2000 [PDF]
, 2000 The project aims to develop emulsified scale inhibitor systems suitable for application as squeeze treatments, particularly in water-sensitive wells and those with poor pressure support. The developed emulsion will be evaluated and the potential benefits
Beare, Steve
core
Deployment, Monitoring, and Optimization of a Scale Inhibitor and Associated Corrosion Inhibitor Within a Deepwater Subsea Facility Offshore Brazil [PDF]
, 2011 Summary This paper presents field results and lessons learned from a floating production, storage, and offloading (FPSO) vessel, offshore Brazil where a scale and combination scale inhibitor (SI) and corrosion inhibitor (Cl) has been ...
S.. Linares-Samaniego +2 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source