Results 101 to 110 of about 5,116,539 (328)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Observable Gravity Waves from Supersymmetric Hybrid Inflation II

, 2010
It is shown that a tensor-to-scalar ratio close to r = 0.03, which can be observed by Planck, is realized in supersymmetric hybrid inflation models with TeV-scale soft supersymmetry breaking terms. This extends our previous analysis, which also found r
Rehman, Mansoor Ur, Shafi, Qaisar, Wickman, Joshua R.   +2 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Ultrasound gray scale ratio for differential diagnosis of papillary thyroid microcarcinoma from benign micronodule in patients with Hashimoto's thyroiditis. [PDF]

BMC Endocr Disord, 2022
Han Z, Xie L, Wei P, Lei Z, Ding Z, Zhang M.   +5 more
europepmc   +1 more source

Relevance of Aβ42/40 Ratio for Detection of Alzheimer Disease Pathology in Clinical Routine: The PLMR Scale

Frontiers in Aging Neuroscience, 2018
Background: Cerebrospinal fluid (CSF) biomarkers (Aβ peptides and tau proteins) improved the diagnosis of Alzheimer’s disease (AD) in research and clinical settings.
Sylvain Lehmann, Sylvain Lehmann, Constance Delaby, Constance Delaby, Guilaine Boursier, Cindy Catteau, Nelly Ginestet, Laurent Tiers, Aleksandra Maceski, Sophie Navucet, Claire Paquet, Julien Dumurgier, Eugeen Vanmechelen, Hugo Vanderstichele, Audrey Gabelle, Audrey Gabelle, Audrey Gabelle   +16 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Accuracy of Berg balance scale to predict falls among community elderly dwellers

Nursing Practice Today, 2015
Background & Aim: Berg balance scale (BBS) is one of the most applied tests to identify high-risk elderly people for fall. Fall is a common health problem among community senior citizens.
Ali Dadgari, Tengku Aizan Hamid, Mohammad Nazrul Hakim, Reza Chaman, Seyed Abbas Mousavi, Lim Poh Hin, Leila Dadvar   +6 more
doaj  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Results of prevalence study regarding comorbilities for various patients [PDF]

Revista Română de Statistică, 2013
It is known that health problem represents an object of permanent study. The study to prevent chronic diseases, factors involved to keep the health status, means to improve the effect of various diseases/affections have been and are appreciated.
A. Capisizu , A. Zamfirescu, S.M. Aurelian, I. Dina   +3 more
doaj  

Scale-model tests of railway rolling noise

Mechanical Engineering Journal, 2019
The rolling noise generated by railway vehicles was evaluated in scale-model tests. The similarity relations associated with wheel/rail noise were derived and the full-scale phenomena were estimated from the scale-model tests. When converting scale-model
Takeshi SUEKI, Toshiki KITAGAWA, Toru YAMAZAKI   +2 more
doaj   +1 more source