Results 131 to 140 of about 5,116,539 (328)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
An Extension of Cross Redundancy of Interval Scale Outputs and Inputs in DEA
Journal of Applied Mathematics, 2013 It is well known that data envelopment analysis (DEA) models are sensitive to selection of input and output variables. As the number of variables increases, the ability to discriminate between the decision making units (DMUs) decreases. Thus, to preserve
Farhad Hosseinzadeh-Lotfi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Full-Scale Modeling and FBGs Experimental Measurements for Thermal Analysis of Converter Transformer
SensorsAs the imbalance between power demand and load capacity in electrical systems becomes increasingly severe, investigating the temperature variations in transformers under different load stresses is crucial for ensuring their safe operation.
Fan Yang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Effect of Influent COD/N Ratio on Nitrification Rate in a Bench-scale Biological Reactor [PDF]
آب و فاضلاب, 2005 Nitrification, the oxidation of ammonia to nitrate catalyzed by bacteria, is a key part of the global nitrogen cycle. In the first step of nitrification, chemolithoautotrophic ammonia oxidizers transform ammonia to nitrite, which subsequently oxidizes to
Bijan Bina +2 more
doaj
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Empirical evaluation of axioms fundamental to Stevens’s ratio-scaling approach: I. Loudness production [PDF]
, 2000 Wolfgang Ellermeier, GÜnther Faulhammer
openalex +1 more source