Results 231 to 240 of about 9,624,872 (292)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Trajectories and associated factors of life-space in older patients following percutaneous coronary intervention: a mixed-methods study. [PDF]

J Health Popul Nutr
Zhang Y, Yang B, Wang Y, Cheng K.
europepmc   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Alpha-N-acetylglucosaminidase (NAGLU) inactivation causes morphological damage to the ultrastructural appearance of epididymal mononuclear phagocytes (eMPs) and epithelial cells of the epididymis in adult mice. [PDF]

PLoS One
Carvelli L, Hermo L, Cyr DG, Gregory M, Pshezhetsky AV, Morales CR.   +5 more
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Phys-Mamba: Physics-informed selective state-space fusion network for high-fidelity underwater image restoration. [PDF]

PLoS One
Li H, Li W, Lao Y, Li J, He J, Wu C, Zhong H, Huang S.   +7 more
europepmc   +1 more source

Global Patterns and Drivers of Climatic Niche Originality and Overlap: Disentangling Ecological From Methodological Signals. [PDF]

Ecol Evol
Chevalier M, Violet C, Boyé A.
europepmc   +1 more source

From EEG Source Localization to Brain Network Analysis: A Computational Neuroscience Perspective. [PDF]

Biology (Basel)
Lee J, Eom TH.
europepmc   +1 more source

Nonlinear Projection for Ballistic Correlation Functions: a Formula in Terms of Minimal Connected Covers. [PDF]

J Stat Phys
Doyon B.
europepmc   +1 more source

Progress and Bottlenecks in Large-Scale Commercial Space Transportation Systems. [PDF]

Research (Wash D C)
Wang X, Song Z, Bao W.
europepmc   +1 more source